Pulpy Kidney
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- Pulpy kidney disease in well-fed 3-10 week-old lambs
- Follows overeating high grain diet or luchious pasture
- Starch from partially digested food enterering the intestine from the rumen allows rapid clostridial proliferation
- Epsilon toxin activated by proteolytic enzymes causes toxaemia
- Epsilon toxin increases intestinal and capillary permeability; also alpha toxin
- Lambs found dead or with opisthotonos, convulsions, coma in acute phases
- Blindness and head pressing in subacute disease; bloat in later stages
- Hyperglycaemia, glycosuria
- Post mortem: hyperaemia in intestine; fluid in pericardial sac; kidney autolysis with pulpy cortical softening (acute death)
- Subacute death causes symmetrical encephalomalacia and haemorrhage in basal ganglia and midbrain
- Enterotoxaemia in kids and adult goats