Canine Adenovirus 1

Infects and replicates in the oropharynx
Viremia as the virus reaches endothelial cells
Attacks the endothelial lining of gall bladder, liver sinusoids, and Kuppfer cells
Resulting heptatitis is followed by severe abdominal pain and often death
Post Mortem: swollen, hemorrhagic liver, ascites, and oedema of the gall bladder
In older dogs, may present more mildly with lymph node enlargement and chronic interstitial nephritis
In foxes: virus replicates in the endothelia of the brain resulting in neuronal damage, fits, and paralysis

Transfers easily via ingesting infected urine, feces or respiratory secretions
Can be transferred by handlers, infected surfaces, etc.

Intranuclear inclusion bodies in hepatocytes can be seen under H&E staining
Vascular endothelium can be stained for viral antigen by immunofluorescence

In an outbreak

To prevent

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