Villus atrophy with intact/hypertrophic crypt glands

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  • Insult affects the villus enterocytes leading to increased loss.
    • Under mild insult, villi may fully regenerate.
    • Severe insult leads to immature cells on the villus.
      • Secrete water and electrolytes into lumen.
  • Examples include:
    • Rotavirus, Coronavirus
      • Infect villus enterocytes.
    • Coccidia
      • Infect surface enterocytes.
    • Nematodes
      • Abrase surface.