Megacolon

Description

Megacolon is a state of permanently increased diameter of the large bowel. This change in intestinal structure leads to abnormal function, including reduced colonic motility and chronic constipation. The condition most commonly occurs in cats and dogs, but pigs can also be afffected. White foals suffering congenital colonic agangliosis, an autosomal recessive trait, may develop secondary megacolon.

In cats and dogs, megacolon may be congenital, acquired or idiopathic. Congenital megacolon in small animals has not been well studied, but is thought to be due to an absence of colonic ganglionic cells. Chronic retention of faeces and distension of the colon irreversibly damages colonic motility to cause acquired megacolon. Idiopathic megacolon is seen primarily in cats, and it has recently been suggested this condition may involve changes to normal colonic smooth muscle function. In many cases, the aetiology of megacolon is not determined.