Canine Leukocyte Adhesion Deficiency

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(CLAD)

  • Occurs in Irish Setters
  • Missence mutation of -Cys-36-Ser- in CD18 molecule
    • CD18 is required for neutrophil migration and phagocytosis
  • Recurrent bacterial infection
  • Neutrophilia (neutrophils remain in the blood and are unable to fight infection in the tissue)
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