Difference between revisions of "Bovine Respiratory Syncytial Virus"

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(New page: {{unfinished}} {{toplink |linkpage =Viruses |linktext =VIRUSES |sublink1=Paramyxoviridae |subtext1=PARAMYXOVIRIDAE |pagetype =Bugs }} <br> ====Pathogenesis==== *More serious than [[Para...)
 
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====Pathogenesis====
 
====Pathogenesis====
*More serious than [[Paramyxoviridae#Parainfluenza -3 (PI-3)|PI-3]]
+
*More serious than [[Bovine Parainfluenza - 3 (PI-3)|PI-3]]
 
*Causes [Respiratory Viral Infections - Pathology#Respiratory syncytial virus|respiratory infection]]
 
*Causes [Respiratory Viral Infections - Pathology#Respiratory syncytial virus|respiratory infection]]
 
*Replicates in nasal epithelium -> throughout upper respiratory tract -> bronchial tree
 
*Replicates in nasal epithelium -> throughout upper respiratory tract -> bronchial tree
 
*Syncytia form -> shed into bronchioles
 
*Syncytia form -> shed into bronchioles
 
*Complications include [[Lungs Ventilation - Pathology#Emphysema|emphysema]] and [[Lungs Circulatory - Pathology#Pulmonary oedema|oedema]], drop in milk yield in adult cattle
 
*Complications include [[Lungs Ventilation - Pathology#Emphysema|emphysema]] and [[Lungs Circulatory - Pathology#Pulmonary oedema|oedema]], drop in milk yield in adult cattle
 +
 
====Epidemiology====
 
====Epidemiology====
 
**Subclinical reinfections are important in spreading disease
 
**Subclinical reinfections are important in spreading disease

Revision as of 18:55, 13 October 2008



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VIRUSES
PARAMYXOVIRIDAE




Pathogenesis

  • More serious than PI-3
  • Causes [Respiratory Viral Infections - Pathology#Respiratory syncytial virus|respiratory infection]]
  • Replicates in nasal epithelium -> throughout upper respiratory tract -> bronchial tree
  • Syncytia form -> shed into bronchioles
  • Complications include emphysema and oedema, drop in milk yield in adult cattle

Epidemiology

    • Subclinical reinfections are important in spreading disease
    • More than 70% of cattle in the UK have antibodies to BRSV

Diagnosis

  • Diseased lung tissue from dead animals or centrifuged cells from lung lavage
  • Virus is too fragile for cell culture isolation (often inactivated in transport)
  • Antigen detection by immunocytochemistry for intracytoplasmic viral inclusions containing labelled viral protein
  • Serology: 4-fold rise in ELISA antibody in paired serum samples from several animals

Control

  • Improve husbansry as in PI-3
  • Vaccines are available but not effective as need to stimulate cytotoxic T-cells

Secondary Concerns

  • Reference: Bryson, 1999, Update on calf pneumonia, CPD Veterinary Medicine, 1,3, 90-95