Difference between revisions of "Bovine Respiratory Syncytial Virus"

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====Control====
 
====Control====
 
*Improve husbandry as in [[Bovine Parainfluenza - 3 (PI-3)#Secondary Concerns|PI-3]]
 
*Improve husbandry as in [[Bovine Parainfluenza - 3 (PI-3)#Secondary Concerns|PI-3]]
*Vaccines are available but not effective as need to stimulate [[Lymphocytes - WikiBlood#Cytotoxic CD8+|cytotoxic T-cells]]
+
*Vaccines are available but not effective as need to stimulate [[Lymphocytes#Cytotoxic CD8+|cytotoxic T-cells]]
  
 
====Secondary Concerns====
 
====Secondary Concerns====
 
*<small>'''Reference''': Bryson, 1999, Update on calf pneumonia, CPD Veterinary Medicine, 1,3, 90-95</small>
 
*<small>'''Reference''': Bryson, 1999, Update on calf pneumonia, CPD Veterinary Medicine, 1,3, 90-95</small>
 
[[Category:Pneumovirinae]][[Category:Cattle]]
 
[[Category:Pneumovirinae]][[Category:Cattle]]

Revision as of 12:37, 12 June 2010



(BRSV)

Pathogenesis

  • More serious than PI-3
  • Causes [Respiratory Viral Infections - Pathology#Respiratory syncytial virus|respiratory infection]]
  • Replicates in nasal epithelium -> throughout upper respiratory tract -> bronchial tree
  • Syncytia form -> shed into bronchioles
  • Complications include emphysema and oedema, drop in milk yield in adult cattle

Epidemiology

    • Subclinical reinfections are important in spreading disease
    • More than 70% of cattle in the UK have antibodies to BRSV

Diagnosis

  • Diseased lung tissue from dead animals or centrifuged cells from lung lavage
  • Virus is too fragile for cell culture isolation (often inactivated in transport)
  • Antigen detection by immunocytochemistry for intracytoplasmic viral inclusions containing labelled viral protein
  • Serology: 4-fold rise in ELISA antibody in paired serum samples from several animals

Control

  • Improve husbandry as in PI-3
  • Vaccines are available but not effective as need to stimulate cytotoxic T-cells

Secondary Concerns

  • Reference: Bryson, 1999, Update on calf pneumonia, CPD Veterinary Medicine, 1,3, 90-95