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CNS Development - Anatomy & Physiology (view source)
Revision as of 13:01, 4 August 2011
, 13:01, 4 August 2011no edit summary
[[Image:WIKIVETneuraltubeformation.jpg|thumb|right|150px|Neural Tube Formation - © Sophie Stenner]]
[[Image:WIKIVETneuraltubeformation.jpg|thumb|right|150px|Neural Tube Formation - © Sophie Stenner]]
Development of the Central Nervous System (CNS) includes development of the brain, spinal cord, optic and auditory systems, as well as surrounding supporting cells including ependymal cells, astrocytes, oligodendrocytes and microglia. Information within this page will exclude development of the Peripheral Nervous System (PNS) which includes nerve and ganglia formation. For further information on PNS development, please see the PNS development page.
Development of the Central Nervous System (CNS) includes development of the brain, spinal cord, optic and auditory systems, as well as surrounding supporting cells including ependymal cells, astrocytes, oligodendrocytes and microglia. Information within this page will exclude development of the Peripheral Nervous System (PNS) which includes nerve and ganglia formation. For further information on PNS development, please see the PNS development page.
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For the appropriate development of the CNS a number of important basic requirements must be achieved. For example, the appropriate haemopoeitic cells must differentiate into specific cells (either neurons or glia) and any axons must extend to appropriate positions in order to form synapses. Development of the CNS is a complex process and complete coordination is required to facilitate the correct procedure of cell differentiation and the establishment of the correct intracellular connections.
The Central Nervous System's embryological origin is from the '''neural ectoderm'''. This is formed as the default pathway from ectoderm to neuroectoderm during development. In the presence of the Lateral Plate Mesoderm (LPM) factor however, ectoderm forms epidermis. To overcome this in development the notochord secretes a LPM factor antagonist allowing the formation of neuroectoderm directly above it. This forms the '''neural plate''' and folds to form the '''neural tube'''.
The Central Nervous System's embryological origin is from the '''neural ectoderm'''. This is formed as the default pathway from ectoderm to neuroectoderm during development. In the presence of the Lateral Plate Mesoderm (LPM) factor however, ectoderm forms epidermis. To overcome this in development the notochord secretes a LPM factor antagonist allowing the formation of neuroectoderm directly above it. This forms the '''neural plate''' and folds to form the '''neural tube'''.