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==Introduction==
CAV1 was first isolated by Carbasso in 1954 in from a dog suffering from acute hepatitis and was identical to the virus isolated by Rubarth in 1947. For that reason, CAV1 was originally known as ICH (infectious canine hepatitis) virus. Infection was subsequently shown to be a common occurence in young dogs across the world. In Britain, 82% of dogs were found to have neutralising antibody titres by the time they were 9 months old (Ablett and Baker, 1960). This high incidence of infection is not matched by a similar incidence of clinical hepatitis, and it si now known that many infections are subclinical and that the virus is also responsible for other conditions, e.g. encephalopathy, ocular disease, neonatal disease, chronic hepatitis, and interstitial nephritis. In several countries, the virus has been isolated from throat swabs or lungs from dogs with respiratory disease, and in Britain CAV-1 is thought to be of importane in kennel cough (infectious tracheobronchitis).
Causes [[Canine Infectious Tracheobronchitis]]
Causes [[Canine Infectious Tracheobronchitis]]
CH is caused by a nonenveloped DNA virus, canine adenovirus 1 (CAV-1), which is antigenically related only to CAV-2 (one of the causes of infectious canine tracheobronchitis, Infectious Tracheobronchitis of Dogs). CAV-1 is resistant to lipid solvents and survives outside the host for weeks or months, but a 1-3% solution of sodium hypochlorite (household bleach) is an effective disinfectant.
==Classification==
==Classification==