Canine Adenovirus 2

Also known as: Infectious Canine Laryngotracheitis

Antigenicity

• Some antigenicity shared between CAV 1 and 2, which lends to vaccination

Pathogenesis

• Causes necrosis of the respiratory tract with NO concurrent hepatitis
• Animals present with:
  • Pyrexia
  • Mild depression
  • Nasal/ocular discharges
  • Corneal opacity (not always)
  • Dry, harsh, persistent cough

Epidemiology

• Transfer is same as for CAV 1

Diagnosis

• Virus isolation from respiratory secretions

Control

• Isolate coughing dogs and disinfect premises
• Vaccination: CAV 1 vaccine will cross protect

Adenovirus pneumonia (Image sourced from Bristol Biomed Image Archive with permission)

• Adenoviridae
• Usually mild bronchointerstitial pneumonia, necrosis of bronchiolar and alveolar epithelium, oedema, type II pneumocyte hyperplasia
• May cause necrotising bronchiolitis in immune-deficient dogs (distemper)
• Can be associated with kennel cough described above