Difference between revisions of "Category:Asfarviridae"

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(Created page with '=Introduction= Asfarviridae receives it's name from '''A'''frican '''S'''wine '''F'''ever virus, which is derived from any of this family of viruses. ASF…')
 
 
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=Introduction=
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{{frontpage
Asfarviridae receives it's name from [[African Swine Fever|'''A'''frican '''S'''wine '''F'''ever virus]], which is derived from any of this family of virusesASF is a serious exotic virus that should not be confused with [[Classical Swine Fever]].
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|pagetitle =Asfarviridae
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|pagebody = Asfarviridae contains asfivirus, which is the virus of African Swine FeverThis is a serious exotic virus that should not be confused with [[Classical Swine Fever]].
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|contenttitle =Content
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|contentbody =<big><b>
  
=Morphology=
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<categorytree mode=pages>Asfarviridae</categorytree>
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|logo =ASF logo.jpg
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}}
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==Morphology==
 
*Large, enveloped, icosahedral, '''cytoplasmic''' DNA virus
 
*Large, enveloped, icosahedral, '''cytoplasmic''' DNA virus
  
=Virulence and Pathogenesis=
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==Virulence and Pathogenesis==
 
*Infects either '''upper respiratory tract''' or '''skin''' via '''ticks'''
 
*Infects either '''upper respiratory tract''' or '''skin''' via '''ticks'''
*Enters bloodstream in [[Monocytes - WikiBlood|monocytes]]
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*Enters bloodstream in [[Monocytes|monocytes]]
 
*Reaches viscera and bone marrow within days
 
*Reaches viscera and bone marrow within days
 
*Induces a '''clotting defect''' and '''hemolysis''' in red blood cells
 
*Induces a '''clotting defect''' and '''hemolysis''' in red blood cells
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*General cell signal transduction is blocked, decreasing non-specific immunity
 
*General cell signal transduction is blocked, decreasing non-specific immunity
  
''Acute Virus (Africa)''
 
*Clinical Signs:
 
**Nasal discharge, diarrhoea, reddening of the skin
 
*Death within 7 days
 
*PM: widespread internal hemorrhage
 
 
''Subacute Virus (Europe)''
 
*PM: Petechial hemorrhages may be seen under kidney capsule
 
*Mortality: 30-70%
 
*Survivors may lose body condition, have skin ulcers and joint swelling
 
 
=Epidemiology=
 
*Can persist on infected premises for months
 
*Subacute recovered pigs become antibody-positive carriers
 
*Transfer:
 
**Africa: vertical transfer between '''soft ticks'''
 
**Europe/Africa: '''direct contact''' with carrier pigs, '''aerosol''', infected swill, etc.
 
 
=Diagnosis=
 
*Mortalities with widespread hemorrhage, particularly in lymph nodes
 
*Test to distinguish from  [[Classical Swine Fever]] and [[Porcine Circoviruses]]
 
*Immunofluorescence
 
*PCR
 
  
=Control=
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[[Category:Viral Organisms]]
*No vaccine is available
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[[Category:To_Do_-_Clinical/Viruses]]
Prevention:
 
*Boiling swill
 
*Isolation of sick pigs, domestic pigs from wild pigs
 
*Keep pigs on concrete, not soil (to lessen tick contact)
 

Latest revision as of 23:34, 15 June 2016

Asfarviridae

Asfarviridae contains asfivirus, which is the virus of African Swine Fever. This is a serious exotic virus that should not be confused with Classical Swine Fever.


Morphology

  • Large, enveloped, icosahedral, cytoplasmic DNA virus

Virulence and Pathogenesis

  • Infects either upper respiratory tract or skin via ticks
  • Enters bloodstream in monocytes
  • Reaches viscera and bone marrow within days
  • Induces a clotting defect and hemolysis in red blood cells
  • Also affects lymphocytes:
    • Infects Th cells and causes them not to produce B-stimulating cytokines
    • Antigen-stimulated B-cells undergo apoptosis rather than producing antibody
  • General cell signal transduction is blocked, decreasing non-specific immunity

Pages in category "Asfarviridae"

This category contains only the following page.