Difference between revisions of "Category:Chlamydophila species"

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===Overview===
 
  
*Host adapted and non-host adapted species varying in virulence for different hosts
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[[Category:Bacterial Organisms]]
*Species cause specific diseases in particular hosts
 
*Respiratory, enteric, pleural and reproductive diseases in animals and humans
 
*Conjunctivitis, arthritis, abortion, urethritis, enteritis, pneumonia, encephalomyelitis
 
*Manifestation varies from subclinical to severe systemic infections
 
*Intestinal infections often subclinical and persistent
 
*Human infections usualy acquired from infected birds, causing psittacosis or ornithosis, causing respiratory infections
 
 
 
 
 
===Characteristics===
 
 
 
*Obligate intracellular bacteria
 
*Gram negative bacteria with outer membrane, LPS, ribosomes, DNA and RNA
 
*Peptidoglycan cell wall resistant to lysozyme
 
*Only grow in presence of living eukaryotic cells
 
*Unable to synthesis ATP therefore require intermediates from host cells
 
*Not stained by Gram stain
 
*Two morphological forms
 
**Elementary body, the infective extracellular form, which is small, metabolically inert and osmotically stable; surrounded by cytoplasmic membrane, outer membrane with LPS, but no peptidoglycan
 
**Retiuculate body: larger, metabolically active, osmotically fragile
 
*Elementary body survives in the environment for several days
 
 
 
 
 
===Pathogenesis and pathogenicity===
 
 
 
*Elementary body enters host epithelial cells by receptor-mediated endocytosis
 
*Transformation into larger reticulate body within endosome; known as an inclusion
 
*Reticulate body divides by binary fission to form many new chlamydia cells
 
*Reticulate bodies mature and condense to form elementary bodies
 
*Elementary bodies released from dying host cells after about 72 hours to infect other cells
 
*Persistent infections can occur if replication delayed by environmental conditions such as presence of interferon gamma
 
*Many infections subclinical due to intracellular existence of ''chlamydia'' preventing inflammatory reactions
 
*Chronic infections  may fail to induce an immune response, or may repeatedly stimulate the immune system, causing a delayed hypersensitivity reaction and tissue damage
 
*Prolonged faecal shedding of organisms
 
*Clinical infections occur in non-natural host species
 
*CLinical signs depend on route of infection and degree of exposure
 
 
 
===Diagnosis===
 
 
 
*Direct microscopy of smears and tissues e.g. organs from aborted foetuses, liver/spleen from avian cases
 
*Kosters (modified Ziehl-Neelsen) stain of placental smears shows small red rods
 
*Blue inclusions in cytoplasm of Giemsa-stained cells
 
*Methylene blue stain with darkfield microscopy
 
*Fluorescent antibody stain
 
*Antigen detection kits for diagnosis from swabs
 
*ELISA to detect ''Chlamydophila'' LPS
 
*Isolation in embryonated eggs and McCoy cells as well as animal tissues
 
*PCR to detect chlamydial DNA
 
*Serological tests: complement fixation, ELISA, indirect immunofluorescence
 
 
 
 
 
*May cause [[Joints Inflammatory - Pathology#In Sheep|arthritis in sheep]] and [[Joints Inflammatory - Pathology#In Cattle|arthritis in cattle]]
 
 
 
'''sheep'''
 
*[[:Category:Chlamydophila species|'''''Chlamydia sp.''''']]
 
**Sporadic or outbreaks of lamb polyarthritis
 
**High morbidity, low mortality
 
**Commonly together with conjunctivitis
 
**Most recover but may remain lame
 
 
 
 
 
'''cattle'''
 
 
 
**[[:Category:Chlamydophila species|'''''Chlamydia sp.''''']]
 
***Severe disease in young calves
 
***High mortality
 
***Can be seen in smears of synovial fluid from swollen joints
 
***Oedematous and hyperaemic surrounding tissue
 
***Possibly due to intrauterine infection
 
 
 
 
 
[[Category:Bacteria]]
 
 
[[Category:Gram_negative_bacteria]]
 
[[Category:Gram_negative_bacteria]]
[[Category:To_Do_-_Bacteria]]
 

Latest revision as of 20:57, 5 November 2010

Pages in category "Chlamydophila species"

The following 5 pages are in this category, out of 5 total.