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| − | ====Leptospirosis==== | + | ====[[Leptospirosis - Cats and Dogs]]==== |
| − | *''Leptospirosis icterohaemorrhagica'' - a septicaemic disease which affects the [[Liver - Anatomy & Physiology|liver]]
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| − | *puppies
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| − | *Leptospirosis is an important spirochaetal group of diseases causing disease in animals and humans (zoonotic)
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| − | *Transmission
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| − | **via urine of affected animals
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| − | **organisms can remain viable for weeks in damp conditions
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| − | *method of action
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| − | **cause anaemia via intravascular haemolysis
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| − | =====Clinical=====
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| − | *fever
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| − | *dehydration
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| − | *haemorrhaging from the mucous membranes of the body
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| − | =====Diagnosis=====
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| − | *dark field microscopy on fresh urine is best
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| − | =====Gross=====
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| − | *widespread hameorrhages
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| − | *icterus
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| − | *pale foci in the [[Liver - Anatomy & Physiology|liver]] (not always a constant finding)
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| − | *subcapsular and cortical renal haemorrhages
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| − | =====Microscopically=====
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| − | *foci of necrosis
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| − | *dissociation of hepatocytes form each other (similar to post mortem change)
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| − | *substantial haemosiderin in the Kuppfer cells (from the haemolysis)
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| − | *need to use a silver stain or immunofluorescence to demonstrate the organisms in tissues
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| | ====Salmonellosis==== | | ====Salmonellosis==== |