Difference between revisions of "Category:Rickettsiales"
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Revision as of 20:46, 14 May 2010
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This article is still under construction. |
Overview
- Cause systemic diseases in animals
- Usually use arthropod vectors
- Host and cell type specificity
- Q fever and Rocky Mountain spotted fever are zoonoses
Characteristics
- Non-motile, pleomorphic Gram-negative organisms
- Obligate intracellular pathogens
- Require live cells for culture such as tissue culture cells or embryonated eggs
- Require Romanowsky stains
- Include two families, Rickettsiaceae and Anaplasmataceae
- Rickettsiaceae have cell walls that contain peptidoglycan; they target endothelial cells and leukocytes
- Anaplasmataceae lack cell walls; they target erythrocytes
Epidemiology
- Rickettsiae replicate in gut epithelial cells of arthropod vectors and spread to other organs such as salivary glands and ovaries
- Transmission occurs during feeding on the animal host
- Transovarial or trans-stadial transmission occurs in the arthropod vectors
- Most ricketsiae have limited survival in the environment, apart from Coxiella burnetii, which undergoes aerosol transmission
Pathogenesis and pathogenicity
- Many rickettsiae target endothelial cells of small blood vessels; they produce phospholipase which damages phagosome membranes, escaping into the cytoplasm
- Ehrlichia target leukocytes or platelets, and inhibit phagosome/lysosome fusion
- Anaplasmataceae localise within vacuoles or on the surface of red blood cells; they may alter red cell antigens causing immune-mediated damage. Anaemia may result from haemolysis or removal of red blood cells
Identification
- Giemsa-stained blood or tissue smears identify blue/purple organisms
- Fluorescent antibody technique for specific identification
- Isolation in embryonated eggs or tissue culture lines
- Nucleic acid probes and PCR
- Inoculation of susceptible animals
Pages in category "Rickettsiales"
The following 11 pages are in this category, out of 11 total.