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Chlamydia Species - General Characteristics (view source)
Revision as of 21:38, 28 November 2022
, 21:38, 28 November 2022no edit summary
===Overview===
==Introduction==
Chlamydia species include host adapted and non-host adapted species varying in virulence for different hosts. They can casue various diseases, including respiratory, enteric, pleural and reproductive diseases in animals and humans; specific conditions include conjunctivitis, arthritis, abortion, urethritis, enteritis, pneumonia, encephalomyelitis. Disease manifestation varies from subclinical to severe systemic infections - intestinal infections are often subclinical and persistent.Human infections are commonly acquired from infected birds with psittacosis or ornithosis, causing respiratory infections in the handler.
==Bacterial Characteristics==
Chlamydia species are obligate intracellular Gram negative bacteria with ribosomes, DNA and RNA and an outer membrane containing lipopolysaccharides (LPS). The peptidoglycan cell wall is resistant to lysozymes.
These bacteria only grow in the presence of living eukaryotic cells as they are unable to synthesise ATP therefore requiring intermediates from host cells. There are two morphological forms:
*Elementary body, the infective extracellular form, which is small, metabolically inert and osmotically stable; surrounded by cytoplasmic membrane, outer membrane with LPS, but no peptidoglycan
*Reticulate body: larger, metabolically active, osmotically fragile
The elementary body survives in the environment for several days.
==Pathogenesis and Pathogenicity==
The elementary body enters the host epithelial cells by receptor-mediated endocytosis. It is subsequently transformation into a larger reticulate body within endosome known as an '''inclusion''', which divides by binary fission to form many new chlamydia cells. The reticulate bodies mature and condense to form elementary bodies which are released from the dying host cells approximately 72 hours after infection to infect other cells. Persistent infections can occur if replication is delayed by environmental conditions such as the presence of interferon gamma.
Many infections are subclinical due to the intracellular existence of ''chlamydia'' which avoids the body's inflammatory response. Chronic infections may fail to induce any immune response, or may repeatedly stimulate the immune system, causing a delayed hypersensitivity reaction and tissue damage. Prolonged faecal shedding of organisms is a common sequelae. Clinical signs of infection depend on the route of infection and degree of exposure.
Clinical infections can occur in non-natural host species.
==Diagnosis of Infection==
*Direct microscopy of smears and tissues e.g. organs from aborted foetuses, liver/spleen from avian cases
*Direct microscopy of smears and tissues e.g. organs from aborted foetuses, liver/spleen from avian cases
*Kosters (modified Ziehl-Neelsen) stain of placental smears shows small red rods
*Kosters (modified Ziehl-Neelsen) stain of placental smears shows small red rods
*Serological tests: complement fixation, ELISA, indirect immunofluorescence
*Serological tests: complement fixation, ELISA, indirect immunofluorescence
==Species Specific Infections==
===Sheep===
*Sporadic or outbreaks of lamb polyarthritis
*High morbidity, low mortality
*Commonly occurs together with conjunctivitis
*Most recover but may remain chronically lame
===Cattle===
*Severe disease in young calves
*High mortality
*Can be seen in smears of synovial fluid from swollen joints
*Oedematous and hyperaemic surrounding tissue
*Possibly due to intrauterine infection
[[Category:Chlamydophila species]]
[[Category:Chlamydophila species]]
==Webinars==
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