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[[Image:LH Complement pathway.png|thumb|right|250px|'''Classical and alternative pathways''']]
[[Image:LH Complement pathway.png|thumb|right|250px|'''Classical and alternative pathways''']]
===Classical Pathway===
===Classical Pathway===
<p>Triggered by the binding of antibody to antigen. Only IgM and certain IgG subclasses can activate complement this way.
<p>Triggered by the binding of antibody to antigen. Only [[IgM]] and certain IgG subclasses can activate complement this way.
#Immune complexes trigger complement activation by binding C1.
#Immune complexes trigger complement activation by binding C1.
#*C1 cross-links two antibody molecules
#*C1 cross-links two antibody molecules