Difference between revisions of "Ethylene Glycol Toxicity"
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Severity of clinicals signs is inversely proportional to amount ingested. Time post-ingestion is also important.<ref name="multiples">http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/210900.htm, accessed on 31.10.2010 </ref>. | Severity of clinicals signs is inversely proportional to amount ingested. Time post-ingestion is also important.<ref name="multiples">http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/210900.htm, accessed on 31.10.2010 </ref>. | ||
*'''Dogs:''' Ataxia, depression and other neurological signs, tachycardia, tachypnoea, polydypsia, polyuria, dehydration, anorexia, emesis, miosis, hypothermia | *'''Dogs:''' Ataxia, depression and other neurological signs, tachycardia, tachypnoea, polydypsia, polyuria, dehydration, anorexia, emesis, miosis, hypothermia | ||
− | **coma and death, or if lesser amount ingested oliguric renal failure within 2 to 7 days after ingestion .<ref name="multiples">http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/210900.htm, accessed on 31.10.2010 </ref>, <ref> '''BSAVA Manual of Canine and Feline Emergency Care'''(Second Edition 2007)</ref>. | + | **coma and death, or if lesser amount ingested oliguric renal failure within 2 to 7 days after ingestion .<ref name="multiples">http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/210900.htm, accessed on 31.10.2010 </ref>, <ref name=multiples> '''BSAVA Manual of Canine and Feline Emergency Care'''(Second Edition 2007)</ref>. |
+ | *'''Cats:''Ataxia, pronounced depression and other neurological signs, tachycardia, tachypnoea, polyuria, dehydration, anorexia, emesis, miosis <ref name="multiple">'''The 5-Minute Veterinary Consult, Canine and Feline''' (Second Edition),''Lippencott, Williams and Wilkins </ref>, <ref name=multiples> '''BSAVA Manual of Canine and Feline Emergency Care'''(Second Edition 2007)</ref>. | ||
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Revision as of 17:02, 31 October 2010
This article is still under construction. |
Introduction
Ethylene Glycol is a sweet tasting fluid that is the main constituent of anti-freeze products.[1]. Consequently in colder climates ethylene glycol toxicity is frequently encountered in practice. It has a relatively low minimum lethal dose, and its sweet, palatable taste makes it attractive to dogs, cats and other small animals. [1], [2],[3]
Signalment
- Dogs: all ages, both sexes, following intoxication lower incidence of fatalities in dogs compared to cats [1]
- Cats: all ages, both sexes
- Birds
- Other including pigs and cattle [3]
Diagnosis
Clinical Signs
Severity of clinicals signs is inversely proportional to amount ingested. Time post-ingestion is also important.[3].
- Dogs: Ataxia, depression and other neurological signs, tachycardia, tachypnoea, polydypsia, polyuria, dehydration, anorexia, emesis, miosis, hypothermia
- 'Cats:Ataxia, pronounced depression and other neurological signs, tachycardia, tachypnoea, polyuria, dehydration, anorexia, emesis, miosis [1], [3].
Laboratory Tests
Pathology
Treatment
Ethylene Glycol is a weak acid. Therefore in order to increase the rate of renal clearance sodium bicarbonate can be administered to dogs. Intravenous administration of sodium bicarbonate at a concentration of 1-2 mmol/kg every 3 to 6 hours achieves sufficient alkalinisation of the urine.[4]
Prognosis
References
- ↑ 1.0 1.1 1.2 1.3 The 5-Minute Veterinary Consult, Canine and Feline, Lippencott, Williams and Wilkins Cite error: Invalid
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tag; name "multiple" defined multiple times with different content - ↑ Feline Medicine and Therapeutics
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/210900.htm, accessed on 31.10.2010 Cite error: Invalid
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tag; name "multiples" defined multiple times with different content - ↑ Canine Medicine and Therapeutics (Fourth Edition, 1998),Blackwell Science, p1049