Difference between revisions of "Feline Herpesvirus 1"
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(New page: {{unfinished}} {{toplink |linkpage =Viruses |linktext =VIRUSES |sublink1=Herpesviridae |subtext1=HERPESVIRUSES |pagetype =Bugs }} <br> ====Pathogenesis==== *[[Respiratory Viral Infection...) |
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====Pathogenesis==== | ====Pathogenesis==== | ||
| − | *[[Respiratory Viral Infections - Pathology#Feline viral rhinotracheitis| | + | *Upper respiratory tract infection: [[Respiratory Viral Infections - Pathology#Feline viral rhinotracheitis|Feline Viral Rhinotracheitis]] |
| + | **Viruses and bacteria are involved in the complex | ||
| + | ** The most frequent aetiologic agent is FHV-1, and less frequently feline calicivirus and/or [[Chlamydia and Chlamydophila species|''Chlamydophia psittaci'']] | ||
| + | **All three agents infect URT respiratory epithelium, although FHV-1 has the highest affinity for this epithelium | ||
| + | ***Feline calicivirus more frequently infects the oral mucosa -> ulcerative stomatitis | ||
| + | ***C.psittaci more frequently infects the conjunctival epithelium -> chronic conjunctivitis | ||
| + | **Infection of the respiratory epithelium by FHV-1 results in a typical neutrophilic rhinitis with intraepitheial intranuclear eosinophilic inclusion bodies, with expected clinical signs | ||
| + | **Resolution of clinical signs usually occurs by 7-14 days | ||
| + | **FHV-1 remains '''latent''' in the trigeminal ganglion, and can reactivate at times of stress: Can infect the cornea -> ulcerative keratitis | ||
| + | **Occasional mortality in kitten or immunocompromised animals usually associated with secondary bacterial infection | ||
*Erosions can affect the bronchi, resulting in '''interstitial pneumonia''' | *Erosions can affect the bronchi, resulting in '''interstitial pneumonia''' | ||
*Most common cause of '''keratitis''' and '''corneal ulcers''' in cat and '''gummy eyes''' in kittens | *Most common cause of '''keratitis''' and '''corneal ulcers''' in cat and '''gummy eyes''' in kittens | ||
Revision as of 20:38, 29 October 2008
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This article is still under construction. |
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Pathogenesis
- Upper respiratory tract infection: Feline Viral Rhinotracheitis
- Viruses and bacteria are involved in the complex
- The most frequent aetiologic agent is FHV-1, and less frequently feline calicivirus and/or Chlamydophia psittaci
- All three agents infect URT respiratory epithelium, although FHV-1 has the highest affinity for this epithelium
- Feline calicivirus more frequently infects the oral mucosa -> ulcerative stomatitis
- C.psittaci more frequently infects the conjunctival epithelium -> chronic conjunctivitis
- Infection of the respiratory epithelium by FHV-1 results in a typical neutrophilic rhinitis with intraepitheial intranuclear eosinophilic inclusion bodies, with expected clinical signs
- Resolution of clinical signs usually occurs by 7-14 days
- FHV-1 remains latent in the trigeminal ganglion, and can reactivate at times of stress: Can infect the cornea -> ulcerative keratitis
- Occasional mortality in kitten or immunocompromised animals usually associated with secondary bacterial infection
- Erosions can affect the bronchi, resulting in interstitial pneumonia
- Most common cause of keratitis and corneal ulcers in cat and gummy eyes in kittens
- Rupture is a particular risk
Epidemiology
- Widespread
- Serious infection
- Latent infection can be reactivated on boarding
Diagnosis
- Nasal swabs on first week of infection can be cultured for virus isolation
Treatment
For keratitis with corneal ulcers:
- Subcut omega interferon
- Topical trifluorothymidine (thymidine analogue) on eyes
Control
- Killed and live vaccines are available
- Live vaccines have provoked symptoms in immunosuppressed kittens and are no longer used in the UK