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| | ====Gross==== | | ====Gross==== |
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| − | * Virus targets crypt cells and lymphoid areas.
| + | The virus targets crypt cells and lymphoid areas,causing [[:Category:Enteritis, Villus Atrophy|villus atrophy]]. In the cat, the intestine becomes thickened, turgid and swollen, with a pale, dull and mottled appearance. |
| − | ** Causes [[:Category:Enteritis, Villus Atrophy|villus atrophy]].
| + | |
| − | * In the cat, the intestine is thickened, turgid and swollen.
| + | The contents appear rather dry, and this becomes increasingly evident lower down the gut. |
| − | ** Has a pale, dull and mottled appearance.
| + | |
| − | ** The contents are rather dry - this gets worse lower down the gut.
| + | Lower down in the gut, enteritis is apparent. In the cat this is fibrinous enteritis, and in the dog it is haemorrhagic. |
| − | * Areas of depression in the mucosa can be seen in the upper small bowel.
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| − | ** Due to necrosis of tissue overlying Peyers patch.
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| − | * Lower down in the gut, enteritis is apparent.
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| − | ** Cat- fibrinous.
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| − | ** Dog- haemorrhagic.
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| − | *** Blood in lumen.
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| − | ** Inflammation sometimes doesn't appear very severe.
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| − | * There may be very few lesions
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| − | ** Histology is usually required for diagnosis.
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| − | * A '''radiomimetic virus'''.
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| − | ** Affects all rapidly dividing cells and destroys them.
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| − | *** E.g. epithelium in the base of the crypts of [[Small Intestine - Anatomy & Physiology|small intestine]] are killed.
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| | ====Histological==== | | ====Histological==== |
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| − | * The crypt lining cells undergo complete necrosis, but very little inflammation occurs.
| + | The crypt lining cells undergo complete necrosis, but very little inflammation is seen. |
| − | ** Collapse of villous architecture.
| + | Fibrinous exudates may be seen on surface of the mucosa. However,the submucosa and lamina propria are often unaffected. Cyst-like structures are seen in the deepest parts of the glands of the intestinal mucosa after only a few days of infection. These cystic glands are lined with flattened epithelial cells. |
| − | * May be fibrinous exudates on surface of mucosa.
| + | |
| − | * The submucosa and lamina propria are not affected and are left intact.
| + | Inclusion bodies may also be seen, but these are often very hard to find. |
| − | ** Many [[Neutrophils|neutrophils]] in the lamina propria.
| + | |
| − | * Cyst-like structures are seen in the deepest parts of the glands of the intestinal mucosa, if the animal survives for more than a few days.
| + | The [[Lymph Nodes - Anatomy & Physiology|Lymph nodes]] appear pale and oedematous, and almost aplastic. The[[Bone Marrow - Anatomy & Physiology|Bone marrow]] appears pale and fatty looking and is depleted of cells. |
| − | ** Flattened epithelial cells line these cystic glands.
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| − | *** Are enterocytes trying to repair the damage.
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| − | *** However, animals usually die from dehydration or secondary infection before the mucosa recovers.
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| − | * Inclusion bodies may be seen, but these are very hard to find.
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| − | * May get [[Lymphocytes|lymphocyte]] invasion of mucosa.
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| − | * [[Lymph Nodes - Anatomy & Physiology|Lymph nodes]] appear pale and oedematous, and almost aplastic.
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| − | * [[Bone Marrow - Anatomy & Physiology|Bone marrow]] appears pale and fatty looking and is depleted of cells.
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| | [[Category:Parvoviridae]][[Category:Cat]] | | [[Category:Parvoviridae]][[Category:Cat]] |
| | [[Category:To_Do_-_Max]] | | [[Category:To_Do_-_Max]] |