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→Mucosal protectants
===Mucosal protectants===
===Mucosal protectants===
Sucralphate, a complex salt of sucrose and aluminium hydroxide, has been used successfully to treat gastric and duodenal ulcers in man. Its main protective action is through adherence to the ulcerated surface. The
Sucralphate, a complex salt of sucrose and aluminium hydroxide, has been used successfully to treat gastric and duodenal ulcers in man. Its main protective action is through adherence to the ulcerated surface. The
aluminum and magnesium hydroxide buffering agents may have a prostaglandin-stimulating action as a heavy metal effect. The mucosal protective functions stimulated by prostaglandin E are discussed below.
aluminum and magnesium hydroxide buffering agents may have a prostaglandin-stimulating action as a heavy metal effect. The mucosal protective functions stimulated by prostaglandin E are discussed below.
Results of some recent studies of sucralphate in horses indicate questionable efficacy in the treatment of squamous ulcers.(EGUC)
Results of some recent studies of sucralphate in horses indicate questionable efficacy in the treatment of squamous ulcers.(EGUC)
Sucralphate inhibits pepsin, enhances the protective mucusbicarbonate layer, increases local protective prostaglandins and increases binding and enhancement of local epidermal growth factor, all of which allow ulcers to heal. However, sucralphate is only indicated for gastric glandular or duodenal ulcers, not for gastric squamous ulcers. Sucralphate has no effect on the healing of gastric squamous epithelial ulcers in horses, but is effective in treating gastric glandular ulcers. Therefore, sucralphate should not be used alone in the treatment of gastric ulcers in foals or mature horses without an endoscopic examination confirming glandular ulcers (Murray 1994). (Orsini)
Sucralphate inhibits pepsin, enhances the protective mucus bicarbonate layer, increases local protective prostaglandins and increases binding and enhancement of local epidermal growth factor, all of which allow ulcers to heal. However, sucralphate is only indicated for gastric glandular or duodenal ulcers, not for gastric squamous ulcers. Sucralphate has no effect on the healing of gastric squamous epithelial ulcers in horses, but is effective in treating gastric glandular ulcers. Therefore, sucralphate should not be used alone in the treatment of gastric ulcers in foals or mature horses without an endoscopic examination confirming glandular ulcers (Murray 1994). (Orsini)
===Prostaglandin analogues===
===Prostaglandin analogues===