Changes

===Mucosal protectants===

===Mucosal protectants===

 

Sucralfate is a complex salt of sucrose and aluminium hydroxide. It is thought to promote ulcer healing via several mechanisms: adherence to ulcerated mucosa, stimulation of mucus secretion, pepsin inibition, increasing prostgalandin E synthesis and enhancing the local production of epidermal growth factor.(Sanchez)  It has been used effectively to treat and prevent stress-induced ulcers in man and has been recommended for the treatment of glandular ulcers in horses.(murray 1994 in Orsini) However, the effect of sucralfate on equine squamous gastric ulcers remains inconclusive(EGUC) and the product may be ineffective in the alkaline conditions created by acid suppression agents.(123-125 in Sanchez)

Sucralphate, a complex salt of sucrose and aluminium hydroxide, has been used successfully to treat gastric and duodenal ulcers in man. Its main protective action is through adherence to the ulcerated surface. The

Results of some recent studies of sucralphate in horses indicate questionable efficacy in the treatment of squamous ulcers.(EGUC)

Sucralphate  inhibits pepsin, enhances the protective mucus bicarbonate layer, increases local protective prostaglandins and increases binding and enhancement of local epidermal growth factor, all of which allow ulcers to heal. However, sucralphate is only indicated for gastric glandular or duodenal ulcers, not for gastric squamous ulcers. Sucralphate has no effect on the healing of gastric squamous epithelial ulcers in horses, but is effective in treating gastric glandular ulcers. Therefore, sucralphate should not be used alone in the treatment of gastric ulcers in foals or mature horses without an endoscopic examination confirming glandular ulcers (Murray 1994). (Orsini)

===Prostaglandin analogues===

===Prostaglandin analogues===