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===Mucosal protectants===
===Mucosal protectants===
Sucralfate is a complex salt of sucrose and aluminium hydroxide. It is thought to promote ulcer healing via several mechanisms: adherence to ulcerated mucosa, stimulation of mucus secretion, pepsin inibition, increasing prostgalandin E synthesis and enhancing the local production of epidermal growth factor.(Sanchez) It has been used effectively to treat and prevent stress-induced ulcers in man and has been recommended for the treatment of glandular ulcers in horses.(murray 1994 in Orsini) However, the effect of sucralfate on equine squamous gastric ulcers remains inconclusive(EGUC) and the product may be ineffective in the alkaline conditions created by acid suppression agents.(123-125 in Sanchez)
Sucralfate is a complex salt of sucrose and aluminium hydroxide. It is thought to promote ulcer healing via several mechanisms: adherence to ulcerated mucosa, stimulation of mucus secretion, pepsin inibition, increasing prostgalandin E synthesis and enhancing the local production of epidermal growth factor.(Sanchez) It has been used effectively to treat and prevent stress-induced ulcers in man and has been recommended at 10-20mg/kg three times daily for the treatment of glandular ulcers in horses.(murray 1994 in Orsini) However, the effect of sucralfate on equine squamous gastric ulcers remains inconclusive(EGUC) and the product may be ineffective in the alkaline conditions created by acid suppression agents.(123-125 in Sanchez)
===Prostaglandin analogues===
===Prostaglandin analogues===
*ranitidine (Zantac, Zeneca, UK) 7mg/kg TID for 3-4wks
*ranitidine (Zantac, Zeneca, UK) 7mg/kg TID for 3-4wks
*cimetidine 25mg/kg QID for 3-4wks (cheaper but less effective so must be given more frequently)
*cimetidine 25mg/kg QID for 3-4wks (cheaper but less effective so must be given more frequently)
===Treatment problems===
===Treatment problems===