Hypertrophic Osteopathy

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  • Also called hypertrophic pulmonary osteopathy
  • In all species
  • Associated with chronic lesions (intrathoracic neoplasm or space-occupying lesion) usually in the thorax
  • Grossly:
    • Periosteal proliferation of bone on diaphyses of distal limbs
    • Progressive and bilateral
  • Histologically:
    • Hyperaemia of periosteum
    • Deposition of new bone
    • Width of cortex may double in a few weeks
  • Postulated to be due to stimulation of vagus by intrathoracic lesion -> increasing blood floow to extremities -> thickening of periosteum