Author, Bureaucrats, Administrators
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*IgA in alimentary system is produced by plasma cells in the lamina propria
*IgA in alimentary system is produced by plasma cells in the lamina propria
**It is the only Ig that can cross into the lumen of the alimentary tract
**It is the only Ig that can cross into the lumen of the alimentary tract
During lactation the levels of IgA increase so that it becomes the predominant immunoglobulin in the milk (more than IgG). Mucosal epithelium have a “poly Ig receptor” and this bind to the J chain on the IgA and allows IgA to travel across the cell. IgA crosses the cell in a transport vesicle and is released by exocytosis.</p>
During lactation the levels of IgA increase so that it becomes the predominant immunoglobulin in the milk (more than [[IgG]]). Mucosal epithelium have a “poly Ig receptor” and this bind to the J chain on the IgA and allows IgA to travel across the cell. IgA crosses the cell in a transport vesicle and is released by exocytosis.</p>
==Function==
==Function==
*IgA is a "non-inflammatory" isotype as it does not does not activate [[Complement|complement]] by the classical pathway and has no role in opsonisation
*IgA is a "non-inflammatory" isotype as it does not does not activate [[Complement|complement]] by the classical pathway and has no role in opsonisation
**This helps to preserve the mucosal integrity and function
**This helps to preserve the mucosal integrity and function
*Ruminant mucosal IgG subclass similarly is also a poor [[Complement|complement]] activator.</p>
*Ruminant mucosal [[IgG]] subclass similarly is also a poor [[Complement|complement]] activator.</p>
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<center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M|Immunoglobulin M]]</sup></b></center>
<center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M|Immunoglobulin M]]</sup></b></center>