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→Psychoactive Drug Therapy
===Psychoactive Drug Therapy===
===Psychoactive Drug Therapy===
Medication can be very effective; a study by Landsberg & Wilson found that cats treated with clomipramine at a mean dose of 0.54mg/kg showed a 75% reduction in spraying within 4 weeks<ref>Landsberg, G.M., Wilson, A.L. (2005) Effects of clomipramine on cats presented for urine marking. J Am Anim Hosp Assoc. 41(1), 3-11.</ref>. In a meta-analysis of the effectiveness of treatments used for indoor spray marking both fluoxetine and clompiramine were found to reduce spraying by at least 90%<ref>Mills, D.S., Redgate, S.E., Landsberg, G.M. (2011) A Meta-Analysis of Studies of Treatments for Feline Urine Spraying. PlosOne. 6(4), 1-10.</ref>
Psychoactive drug therapy is often prescribed for cats with indoor marking problems. However, to be successful, the '''underlying reasons for the indoor marking must also be addressed'''. Medication does have a role in longstanding cases where the number of marked sites is large, or when marking has become habitual, or there is an emotional problem that may benefit from temporary drug support. Analysis of the general emotional state of the animal is important. SRI/SSRI drugs such as fluoxetine and clomipramine are beneficial for cats that are habitual indoor markers, or show a pattern of anxious, reactionary spraying. Selegiline benefits behaviourally-inhibited cats that will not explore their environment, or that display fearful reactions followed closely by reactionary spraying when they see certain cats lurking outside the home. These drugs will not help confident cats that show no signs of anxiety or fear and are merely using spray marks, albeit inappropriately, as part of a calmly considered strategy to control territory in the house. Hormonal preparations have no role in the treatment of indoor marking.
Psychoactive drug therapy is often prescribed for cats with indoor marking problems. However, to be successful, the '''underlying reasons for the indoor marking must also be addressed'''. Medication does have a role in longstanding cases where the number of marked sites is large, or when marking has become habitual, or there is an emotional problem that may benefit from temporary drug support. Analysis of the general emotional state of the animal is important. SRI/SSRI drugs such as fluoxetine and clomipramine are beneficial for cats that are habitual indoor markers, or show a pattern of anxious, reactionary spraying. Selegiline benefits behaviourally-inhibited cats that will not explore their environment, or that display fearful reactions followed closely by reactionary spraying when they see certain cats lurking outside the home. These drugs will not help confident cats that show no signs of anxiety or fear and are merely using spray marks, albeit inappropriately, as part of a calmly considered strategy to control territory in the house. Hormonal preparations have no role in the treatment of indoor marking.
'''The decision to use psychoactive drugs for indoor marking'''
'''The decision to use psychoactive drugs for indoor marking'''