Infectious Canine Hepatitis

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  • adenovirus - Canine Adenovirus 1
  • also known as Rubarth's Disease, Canine adenovirus infection
  • acute and generalised infection
  • young dogs
  • highly infectious
  • spread via the urine of infected animals over a long period of time
Clinical
  • lymph nodes and tonsils are enlarged and reddened, sometimes haemorrhagic
  • recovering animals may show an immune-mediated uveitis with corneal opacity
Gross
  • the virus has a tropism for endothelium and hepatocytes
    • widespread haemorrhages, especially on serosal surface
  • distinctly pale mottled appearance
    • from extensive necrosis, characteristically periacinar (centrilobular) in distribution - the reason for the increased susceptibility of this area is not known
  • enlarged
  • friable
  • fibrinous or fibrino-haemorrhagic strands between lobes
  • gall bladder
    • wall usually shows oedema (up to 2cm diameter)
Microscopically
  • basophilic intranuclear inclusion bodies
    • in hepatocytes and macrophages