Changes

* The macula densa releases prostaglandins which act on the juxtaglomerular apparatus which releases renin into the bloodstream.

* The macula densa releases prostaglandins which act on the juxtaglomerular apparatus which releases renin into the bloodstream.

* The drop in blood pressure is also detected by baroreceptors in the aortic arch, carotid sinus and the afferent renal arteriole which stimulates renin release by the juxtaglomerular apparatus.

* The drop in blood pressure is also detected by baroreceptors in the aortic arch, carotid sinus and the afferent renal arteriole which stimulates renin release by the juxtaglomerular apparatus.

* Renin cleaves angiotensinogen into angiotensin 1 which in turn is cleaved by [[Angiotensin Converting Enzyme (ACE) - Renal Anatomy & Physiology|'''Angiotensin Converting Enzyme''' (ACE)]]  into angiotensin 2.

* Renin cleaves angiotensinogen into angiotensin 1 which in turn is cleaved by [[Angiotensin Converting Enzyme (ACE) - Anatomy & Physiology|'''Angiotensin Converting Enzyme''' (ACE)]]  into angiotensin 2.

* Angiotensin 2 is a potent vasoconstrictor and also stimulates the adrenal cortex to release [[Aldosterone|aldosterone]].

* Angiotensin 2 is a potent vasoconstrictor and also stimulates the adrenal cortex to release [[Aldosterone|aldosterone]].

* [[Aldosterone|Aldosterone]] acts on the distal tubules and collecting ducts in the kidney causing retention of sodium and water.

* [[Aldosterone|Aldosterone]] acts on the distal tubules and collecting ducts in the kidney causing retention of sodium and water.