Changes

== Introduction ==

== Introduction ==

Any hepatic injury of a moderate degree or more, is going to cause a degree of fibrosis when the lesion has resolved. Fibrosis occurs due to proliferation of the supportive connective tissue in the liver. Fibrosis isolates the [[Liver - Anatomy & Physiology|liver]] cells by effectively changing the sinusoids into capillaries and when a certain amount of fibrosis occurs, it can be self-perpetuating, the end result is a small scarred liver with functional failure.

Fibrosis is one way in which the liver responds to injury. It commonly occurs in association with chronic hepatic injury, and represents a repair stage in response to diseases that lead to [[Liver Necrosis|necrosis]] and inflammation. The process is complex and involves increased deposition of extracellular matrix in the liver, following injury-induced activation of [[Hepatic Stellate Cells|stellate cells]].

The distribution pattern of fibrosis is a reflection of the pathogenesis of the condition, and can indicate the type of underlying pathology.

==Patterns of Fibrosis ==

==Patterns of Fibrosis ==