Difference between revisions of "Louping Ill"

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*Human vaccination where at risk
 
*Human vaccination where at risk
 
[[Category:Flaviviruses]][[Category:Sheep]][[Category:Poultry]][[Category:Zoonoses]][[Category:Rodents]]
 
[[Category:Flaviviruses]][[Category:Sheep]][[Category:Poultry]][[Category:Zoonoses]][[Category:Rodents]]
 +
[[Category:To_Do_-_Viruses]]

Revision as of 22:38, 26 June 2010



Hosts

  • Sheep
  • Grouse
  • Hares
  • Deer elk
  • Small rodents
  • Ticks (eg. Ixodes ricinus)
  • Man

Pathogenesis

  • First phase:
    • Pyrexia with virus in macrophages
    • Recovery
  • Second phase:
    • Second replication in Purkinje cells of the cerebellum and motor nuclei of the brain stem
    • Trembling, torticollis, and irregular gait
    • In grouse: starvation
    • In man: flu-like symptoms can be followed by coma, but recovery normal

Epidemiology

  • Reservoir host: Ticks (Ixodes ricinus)
    • Passed to host by saliva
    • Virus can be spread between ticks when co-feeding on small rodents
  • Spread mirrors seasonal tick activity

Diagnosis

  • Clinical signs
  • PM: virus isolation and histopathology of brain tissue

Control

  • Sheep dipping in acaracides (vector control)
  • Inactivated vaccines in late pregnancy can boost maternal antibody
    • Lambs inoculated >4 months of age
  • Human vaccination where at risk