Changes

===Capsule and reticular framework===

===Capsule and reticular framework===

<p> The nodes are surrounded by a fibrous capsule that extends into the node as trabeculae, which provide an overall framework. Below the capsule is the subcapsular sinus. The nodes' parenchyma contain a fine network of reticular fibres and reticular cells. Reticular cells provide "scaffolding" for other cells as well as expressing surface complexes and substance to attract [[Lymphocytes#T cells|T cells]], [[Lymphocytes#B cells|B cells]] and [[T cell differentiation - WikiBlood#Dendritic Cells|dendritic cells]].  

<p> The nodes are surrounded by a fibrous capsule that extends into the node as trabeculae, which provide an overall framework. Below the capsule is the subcapsular sinus. The nodes' parenchyma contain a fine network of reticular fibres and reticular cells. Reticular cells provide "scaffolding" for other cells as well as expressing surface complexes and substance to attract [[Lymphocytes#T cells|T cells]], [[Lymphocytes#B cells|B cells]] and [[T cell differentiation - WikiBlood#Dendritic Cells|dendritic cells]].  

The cortex has aggregations of [[Lymphocytes#B cells|B cells]] (in the follicles) in its outer region and a paracortex consisting of a rim of [[Lymphocytes#T cells|T cells]] surrounding these follicles. [[T cell differentiation - WikiBlood#Dendritic Cells|Dendritic cells]] are also found in close association with the [[Lymphocytes#T cells|T cells]].  The medulla contains medullary cords of cells ([[Lymphocytes#B cells|B cells]], plasma cells and some [[Macrophages - WikiBlood|macrophages]]) and between these cords is the medullary sinus lined with endothelial cells and [[Macrophages - WikiBlood|macrophages]].</p>

The cortex has aggregations of [[Lymphocytes#B cells|B cells]] (in the follicles) in its outer region and a paracortex consisting of a rim of [[Lymphocytes#T cells|T cells]] surrounding these follicles. [[T cell differentiation - WikiBlood#Dendritic Cells|Dendritic cells]] are also found in close association with the [[Lymphocytes#T cells|T cells]].  The medulla contains medullary cords of cells ([[Lymphocytes#B cells|B cells]], plasma cells and some [[Macrophages|macrophages]]) and between these cords is the medullary sinus lined with endothelial cells and [[Macrophages|macrophages]].</p>

===Sinuses===

===Sinuses===

**Drain lymph from subcapsular to medullary sinuses

**Drain lymph from subcapsular to medullary sinuses

*Medullary

*Medullary

Antigens and transformed cells that pass through the sinuses are filtered by [[Macrophages - WikiBlood|macrophages]] and removed from the lymph.</p>

Antigens and transformed cells that pass through the sinuses are filtered by [[Macrophages|macrophages]] and removed from the lymph.</p>

==Follicles==

==Follicles==