Changes

* Preformed mediators such as serotonin, histamine, proteoglycans, heparin and serine proteases (tryptase and/or chymase)

* Preformed mediators such as serotonin, histamine, proteoglycans, heparin and serine proteases (tryptase and/or chymase)

* Lipid mediators such as leukotrienes and prostaglandin D2

* Lipid mediators such as leukotrienes and prostaglandin D2

* Cytokines: Il-3, Il-4, Il-5, Il-6, Il-8, Il-13, Il-16 TNF-α</p>

* Cytokines: IL-3, IL-4, IL-5, IL-6, IL-8, IL-13, IL-16 and TNF-α</p>

*Chemotactic factors for both [[Neutrophils|neutrophils]] and [[Eosinophils|eosinophils]]

* Chemotactic factors for both [[Neutrophils|neutrophils]] and [[Eosinophils|eosinophils]]

<p>Histamine increases vascular permeability, mucous production and smooth muscle tone in the respiratory tract and is responsible for the itch sensation in the skin. Heparin is an anticoagulant and binds with antithrombin III and platelet factor IV to block coagulation factors. Leukotrienes like histamine are responsible for contraction of respiratory smooth muscle. Chymase plays a role in the production of angiotensin II.</p>

<p>Histamine increases vascular permeability, mucous production and smooth muscle tone in the respiratory tract and is responsible for the itch sensation in the skin. Heparin is an anticoagulant and binds with antithrombin III and platelet factor IV to block coagulation factors. Leukotrienes like histamine are responsible for contraction of respiratory smooth muscle. Chymase plays a role in the production of angiotensin II.</p>

<p>Mast Cell granules are thought to produce a ground substance to facilitate collagen formation which occurs during the repair of an injury.</p>

<p>Mast Cell granules are thought to produce a ground substance to facilitate collagen formation which occurs during the repair of an injury.</p>