Difference between revisions of "Nocardia asteroides"

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**Found in soil and decaying vegetation - saprophytic
+
*Found in soil and decaying vegetation - saprophytic
**Opportunistic infection of immunocompromised animals  
+
*Opportunistic infection of immunocompromised animals  
**Infection via inhalation, wounds or teat canal; also ingestion
+
*Infection via inhalation, wounds or teat canal; also ingestion
**Causes granulomatous lesions in animals
+
*Causes granulomatous lesions in animals
**Canine nocardiosis:  
+
*Canine nocardiosis:  
***Thoracic, [[Bacterial skin infections - Pathology#bacterial granulomatous dermatitis|cutaneous]] and disseminated forms
+
**Thoracic, [[Bacterial skin infections - Pathology#bacterial granulomatous dermatitis|cutaneous]] and disseminated forms
***Cutaneous pyogranulomas: ulcers or granulomatous swellings with discharging fistulae  
+
**Cutaneous pyogranulomas: ulcers or granulomatous swellings with discharging fistulae  
***[[Peritonitis - Cats and Dogs|peritonitis]]
+
**[[Peritonitis - Cats and Dogs|peritonitis]]
***[[Respiratory Bacterial Infections - Pathology#Nocardiosis|pleuritis]] and pyothorax with fever, anorexia and respiratory distress
+
**[[Respiratory Bacterial Infections - Pathology#Nocardiosis|pleuritis]] and pyothorax with fever, anorexia and respiratory distress
***Disseminated lesions
+
**Disseminated lesions
***Treat with appropriate systemic antibiotics for 6 weeks
+
**Treat with appropriate systemic antibiotics for 6 weeks
**Cattle: chronic mastitis; abortion
+
*Cattle: chronic mastitis; abortion
**Pigs: abortion
+
*Pigs: abortion
**Sheep, goats, horses: wound infections; mastitis; pneumonia
+
*Sheep, goats, horses: wound infections; mastitis; pneumonia
**Survives and multiplies in macrophages
+
*Survives and multiplies in macrophages
**Superoxide dismutase and catalase as well as a thick peptidoglycan wall prevent activity of phagocytes  
+
*Superoxide dismutase and catalase as well as a thick peptidoglycan wall prevent activity of phagocytes  
**Chronic, progressive disease
+
*Chronic, progressive disease
**Positive modified Ziehl-Neelson
+
*Positive modified Ziehl-Neelson
**Culture on blood agar and incubate under aerobic conditions at 37 degrees centigrade for 10 days
+
*Culture on blood agar and incubate under aerobic conditions at 37 degrees centigrade for 10 days
**White, powdery colonies, adherent to the agar appear after 5 days
+
*White, powdery colonies, adherent to the agar appear after 5 days
**Subculture onto Sabouraud dextrose agar yields wrinkled, orange colonies
+
*Subculture onto Sabouraud dextrose agar yields wrinkled, orange colonies
**Lesions difficult to treat due to resistance of organisms to many antimicrobials (e.g. penicillins)
+
*Lesions difficult to treat due to resistance of organisms to many antimicrobials (e.g. penicillins)
**Cell-mediated immunity required
+
*Cell-mediated immunity required
 
[[Category:Nocardia species]][[Category:Dog]][[Category:Pig]][[Category:Cattle]]
 
[[Category:Nocardia species]][[Category:Dog]][[Category:Pig]][[Category:Cattle]]
 
[[Category:To_Do_-_Bacteria]]
 
[[Category:To_Do_-_Bacteria]]

Revision as of 19:06, 1 November 2010

  • Found in soil and decaying vegetation - saprophytic
  • Opportunistic infection of immunocompromised animals
  • Infection via inhalation, wounds or teat canal; also ingestion
  • Causes granulomatous lesions in animals
  • Canine nocardiosis:
    • Thoracic, cutaneous and disseminated forms
    • Cutaneous pyogranulomas: ulcers or granulomatous swellings with discharging fistulae
    • peritonitis
    • pleuritis and pyothorax with fever, anorexia and respiratory distress
    • Disseminated lesions
    • Treat with appropriate systemic antibiotics for 6 weeks
  • Cattle: chronic mastitis; abortion
  • Pigs: abortion
  • Sheep, goats, horses: wound infections; mastitis; pneumonia
  • Survives and multiplies in macrophages
  • Superoxide dismutase and catalase as well as a thick peptidoglycan wall prevent activity of phagocytes
  • Chronic, progressive disease
  • Positive modified Ziehl-Neelson
  • Culture on blood agar and incubate under aerobic conditions at 37 degrees centigrade for 10 days
  • White, powdery colonies, adherent to the agar appear after 5 days
  • Subculture onto Sabouraud dextrose agar yields wrinkled, orange colonies
  • Lesions difficult to treat due to resistance of organisms to many antimicrobials (e.g. penicillins)
  • Cell-mediated immunity required