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*Low serum trypsin-like immunoreactivity is an early, preclinical diagnostic test for EPI
 
*Low serum trypsin-like immunoreactivity is an early, preclinical diagnostic test for EPI
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*[[Exocrine Pancreatic Atrophy in GSDs and Rough Coated Collies|Further Study]][[Category:Pancreas - Degenerative Pathology ]]
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<big>Extra information for Exocrine Pancreatic Atrophy
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Exocrine pancreatic atrophy in GSDs and rough coated collies: an end result of lymphocytic pancreatitis. Wiberg ME et al. Vet Path (1999) 36 530-41</big>
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*Histological changes in EPI dogs
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*Histological changes in the subclinical pancreas (ie; just TLI):
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*Patchy areas of normal and abnormal exocrine parenchyma
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*Consistently a marked lymphoid infiltrate (lesser numbers of plasma cells seen, occasional eosinophils), starting in the border zone with gradual loss of the pancreatic parenchyma
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*Mainly CD3+ T cells, with fewer CD3+ lymphocytes.
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*Some lymphoid follicles (mainly B cells) scattered throughout.
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*No associated increase in fibrous connective tissue
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*Some intra-acinar lymphocytes seen
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*As tissue destruction continued, ductal structures became more obvious
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*Apoptosis seen in the acini often in normal looking acini.
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*Ultrastructure
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**Degenerative changes in acinar cells – dilation of rER, swelling of mitochondria, nuclear pyknosis, aptotitic bodies
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*Histology of clinical EPI:
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**Totally atrophied exocrine pancreas
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**Some dogs had areas of normal acinar structures
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**Little inflammation in the border zone
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**Most of the remaining exocrine pancreas was disorganized, prominent ducts, increased amounts of adipose tissue.
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**Slight increase in fibrous tissue compared to subclinical phase, but replacement with fat was more prominent than fibrosis.
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**No ductular epithelial hyperplasia evident
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*Ultrastructure
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**Often no remaining acinar cells
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*Suggests and immune-mediated destruction - ?hereditary
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*Islet cells usually well preserved in the atrophied pancreas.
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[[Category:Pancreas - Degenerative Pathology ]]
 
[[Category:Pancreatic Diseases - Dog]]
 
[[Category:Pancreatic Diseases - Dog]]
 
[[Category:To_Do_-_Clinical]]
 
[[Category:To_Do_-_Clinical]]
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