Difference between revisions of "Parturition Endocrine Control - Anatomy & Physiology"
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Details of Oxytocin Synthesis and Secretion may be found [[Endocrine_System_-_Pituitary_Gland_-_Anatomy_%26_Physiology#Oxytocin|here]] | Details of Oxytocin Synthesis and Secretion may be found [[Endocrine_System_-_Pituitary_Gland_-_Anatomy_%26_Physiology#Oxytocin|here]] | ||
| + | |||
| + | * Oxytocin acts to: | ||
| + | ** Increase myometrial contraction (positive feedback) | ||
| + | ** Increase Prostaglandin release | ||
| + | |||
| + | '''Furgesson Reflex''' | ||
Revision as of 12:00, 2 July 2008
Regulation of Prostaglandins
The uterus is an important site of prostaglandin synthesis. During pregnancy, the presence of the foetus inhibits the production of prostaglandins in order to prevent luteolysis. At parturition, an increase in prostaglandin synthesis is required.
- Prostaglandins are synthesized from Arachadonic Acid, which is derived from Glycerophospholipids by the enzyme Phospholipase A2 (PLA2).
- Oestrogen liberates Phospholipase A2 from lysosomes.
- Progesterone stabilises lysosomes, so Phospholipase A2 cannot be liberated from lysosomes.
- An increase in Oestrogen:Progesterone ratio increases prostaglandin production.
- The increase in Oestradiol (bioactive oestrogen) also increases expression of endometrial Oxytocin receptors.
Regulation of Oxytocin
Details of Oxytocin Synthesis and Secretion may be found here
- Oxytocin acts to:
- Increase myometrial contraction (positive feedback)
- Increase Prostaglandin release
Furgesson Reflex