Difference between revisions of "Porcine Circoviruses"
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(New page: {{unfinished}} {{toplink |linkpage =Viruses |linktext =VIRUSES |sublink1=Circoviridae |subtext1=CIRCOVIRUSES |pagetype =Bugs }} <br> *Porcine circovirus in Postweaning multisystemic wast...) |
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| − | *Porcine | + | ====Antigenicity==== |
| + | *Two serotypes: | ||
| + | **PCV1 is harmless | ||
| + | **PCV2 is virulent, causing: | ||
| + | ***Post-weaning Multisystemic Wasting Syndrome (PMWS) in young pigs | ||
| + | ***Porcine Dermatitis and Nephropathy Syndrome (PDNS) in older pigs | ||
| + | |||
| + | ====Pathogenesis==== | ||
| + | '''PMWS''': | ||
| + | *Enlarged lymph nodes with lymphopenia as virus concentrates in germinal centers | ||
| + | *Typically strikes '''weaners''' (8-12 weeks old) | ||
| + | *Clinical signs: | ||
| + | **Pale skin color | ||
| + | **Jaundice | ||
| + | **Enlarged lymph nodes and kidneys | ||
| + | **Unthrifty appearance | ||
| + | **Lameness | ||
| + | **[[Respiratory Viral Infections - Pathology#Postweaning multisystemic wasting syndrome (PMWS)|Respiratory disease]] | ||
| + | **Occasional diarrhoea | ||
| + | *Large range of differentials, particularly [[Classical Swine Fever|Swine Fever]], African Swine Fever, ''Pasteurella'', and colisepticemia | ||
| + | *Mortalities can reach 40% in an outbreak; nationally range from 4-10% annually | ||
| + | '''PDNS''': | ||
| + | *Can follow PMWS | ||
| + | *Seen in '''growers and finishers''' | ||
| + | *Presents as an immune-mediated '''necrotising vasculitis''' | ||
| + | *Extensive hemorrhages of kidneys and skin, especially in the scrotal region, accompanied by pyrexia | ||
| + | |||
| + | ====Epidemiology==== | ||
| + | *Poor immune response | ||
| + | *Transfer is '''orofecal''' and '''venereal''' | ||
| + | |||
| + | ====Diagnosis==== | ||
| + | *Clinical signs | ||
| + | *Confirmed by PCR for PCV2 nucleic acid | ||
| + | *However, positives can show NO clinical signs | ||
| + | |||
| + | ====Control==== | ||
| + | *No vaccines are available | ||
| + | *Antibiotics to prevent secondary infection | ||
| + | *Good ventilation, bio-security, and proper management | ||
| + | *Passive antibody can be used in dire circumstances: | ||
| + | **Viral serum from an adult pig and be injected peritoneally into piglets to stimulate a high anitbody response | ||
| + | **Must be done by a vet and only within a single herd | ||
Revision as of 20:53, 22 October 2008
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This article is still under construction. |
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Antigenicity
- Two serotypes:
- PCV1 is harmless
- PCV2 is virulent, causing:
- Post-weaning Multisystemic Wasting Syndrome (PMWS) in young pigs
- Porcine Dermatitis and Nephropathy Syndrome (PDNS) in older pigs
Pathogenesis
PMWS:
- Enlarged lymph nodes with lymphopenia as virus concentrates in germinal centers
- Typically strikes weaners (8-12 weeks old)
- Clinical signs:
- Pale skin color
- Jaundice
- Enlarged lymph nodes and kidneys
- Unthrifty appearance
- Lameness
- Respiratory disease
- Occasional diarrhoea
- Large range of differentials, particularly Swine Fever, African Swine Fever, Pasteurella, and colisepticemia
- Mortalities can reach 40% in an outbreak; nationally range from 4-10% annually
PDNS:
- Can follow PMWS
- Seen in growers and finishers
- Presents as an immune-mediated necrotising vasculitis
- Extensive hemorrhages of kidneys and skin, especially in the scrotal region, accompanied by pyrexia
Epidemiology
- Poor immune response
- Transfer is orofecal and venereal
Diagnosis
- Clinical signs
- Confirmed by PCR for PCV2 nucleic acid
- However, positives can show NO clinical signs
Control
- No vaccines are available
- Antibiotics to prevent secondary infection
- Good ventilation, bio-security, and proper management
- Passive antibody can be used in dire circumstances:
- Viral serum from an adult pig and be injected peritoneally into piglets to stimulate a high anitbody response
- Must be done by a vet and only within a single herd