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Porcine reproductive and respiratory syndrome was first recognised in the USA in 1987 and spreadto Europe in 1990 and the UK in 1991. Infection in the UK was initially seen in the Humberside area, but despite restrictions being placed on the movement of breeding stock outwith the infected zone, the disease spread to many parts of the country. PRRS is caused by a virus, of which different strains occur in the USA and Europe. The european strains are much milder in terms of their pathogenic potential than the US strains. The acute phase of disease lasts approximately 4-16 weeks. The most consistent featurs are reproductive lossed in pregnant stoock, increased pre-weaning mortality and inluenza-like illness affecting all ages of pigs. American strains of virus are much more virulent than European strains, causing sow martality in addidion to pneumonia and reporductive failure.
 
Porcine reproductive and respiratory syndrome was first recognised in the USA in 1987 and spreadto Europe in 1990 and the UK in 1991. Infection in the UK was initially seen in the Humberside area, but despite restrictions being placed on the movement of breeding stock outwith the infected zone, the disease spread to many parts of the country. PRRS is caused by a virus, of which different strains occur in the USA and Europe. The european strains are much milder in terms of their pathogenic potential than the US strains. The acute phase of disease lasts approximately 4-16 weeks. The most consistent featurs are reproductive lossed in pregnant stoock, increased pre-weaning mortality and inluenza-like illness affecting all ages of pigs. American strains of virus are much more virulent than European strains, causing sow martality in addidion to pneumonia and reporductive failure.
*The syndrome is caused by a small enveloped RNA virus which belongs to the new [[Arteriviridae|Arteriviridae]] group
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*Replicates in and destroys macrophages and endothelial cells causing vasculitis -> viraemia -> virus shedding (nasal secretions, faeces)
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*Clinical signs: respiratory and reproductive failure, weaned pigs, tachypnoea, eyelid oedema, conjunctivitis
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*Moderate to severe interstitial [[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|pneumonia]] in the cranial lobe
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*Superimposed bacterial infections are common
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*Infectious disease in swine that emerged 10 years ago
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*Today, PRRS is endemic in many if not all the pig-producing countries
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PRRS Porcine reproductive and respiratory syndrome virus (Lelystad virus). There is abortion late in gestation with respiratory tract illness in live piglets (interstitial pneumonia).
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Porcine reproductive and respiratory syndrome (PRRS)
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first appeared in the late 1980s, though serologic evidence
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indicates that it had been circulating in swine for
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some time prior to being recognized (Carman, Sanford,
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and Dea, 1995; Dewey, 2000; Ohlinger, Pesch, and
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Bischoff, 2000). PRRS has since become a highly significant
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infectious disease affecting swine production
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worldwide. Abortions, mortality and decreases in growth
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rate and efficiency associated with PRRS all impact
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swine welfare and have a serious economic effect on
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swine production, estimated at over $560 million per
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year in the U.S. alone (Neumann et al., 2005).
    
==Aetiology==
 
==Aetiology==
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