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==Pathogenesis==
 
==Pathogenesis==
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Transmission of PRRS virus to swine occurs most efficiently
+
 
through direct contact. Blood, saliva, urine, milk
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and semen from infected animals have been shown to
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transmit PRRS virus to susceptible swine (Wills et al.,
  −
1997). Aerosol transmission may occur but has proven
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difficult to demonstrate even over relatively short distances
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(meters). Transmission by semen, either
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through natural service or artificial insemination is well
  −
established (Yaeger et al., 1993).
   
Following exposure to PRRS virus, primary replication
 
Following exposure to PRRS virus, primary replication
 
occurs in regional or mucosal macrophages (Rossow,
 
occurs in regional or mucosal macrophages (Rossow,
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