Changes

*AKA contagious pustular dermatitis, Orf, etc

*AKA contagious pustular dermatitis, Orf, etc

===General information===

====General information====

*CE is an acute debilitating but rarely fatal skin disease of sheep, goats and incidentally of ruminants and humans.  

*CE is an acute debilitating but rarely fatal skin disease of sheep, goats and incidentally of ruminants and humans.  

*The disease is generally mild.  

*The disease is generally mild.  

*PPV's generally exhibit a highly restricted host range but in all cases can also infect man.

*PPV's generally exhibit a highly restricted host range but in all cases can also infect man.

===Aetiological agent===

====Aetiological agent====

*The virus is a large, enveloped, highly epitheliotropic, DNA virus which is ovoid in shape and measures 220‑300 x 140‑170 nm.  *There are over 100 polypeptides in the virion.   

*The virus is a large, enveloped, highly epitheliotropic, DNA virus which is ovoid in shape and measures 220‑300 x 140‑170 nm.  *There are over 100 polypeptides in the virion.   

*The core proteins include a transcriptase and several other enzymes.   

*The core proteins include a transcriptase and several other enzymes.   

*The virus is resistant to desiccation.

*The virus is resistant to desiccation.

===Pathology===

====Pathology====

[[Image:f00358.jpg]]

[[Image:f00358.jpg]]

===Differential diagnosis===

====Differential diagnosis====

*  Sheep pox: A more severe disease, it is characterized by elevated papules distributed diffusely over the skin surface.  Inclusion bodies are often seen, but there is no down‑growth of epidermis.  There is a high mortality.

*  Sheep pox: A more severe disease, it is characterized by elevated papules distributed diffusely over the skin surface.  Inclusion bodies are often seen, but there is no down‑growth of epidermis.  There is a high mortality.

*  Ulcerative dermatosis:  Characterized by ulcers and crusts on the skin of the face, feet and genitalia.  The lesions are not elevated because there is no epithelial hyperplasia.

*  Ulcerative dermatosis:  Characterized by ulcers and crusts on the skin of the face, feet and genitalia.  The lesions are not elevated because there is no epithelial hyperplasia.