Pulpy Kidney

Pulpy kidney disease]] in well-fed 3-10 week-old lambs
Caused by Clostridium perfringens type D
Follows overeating high grain diet or luchious pasture
Starch from partially digested food enterering the intestine from the rumen allows rapid clostridial proliferation
Epsilon toxin activated by proteolytic enzymes causes toxaemia
Epsilon toxin increases intestinal and capillary permeability; also alpha toxin
Lambs found dead or with opisthotonos, convulsions, coma in acute phases
Blindness and head pressing in subacute disease; bloat in later stages
Hyperglycaemia, glycosuria
Post mortem: hyperaemia in intestine; fluid in pericardial sac; kidney autolysis with pulpy cortical softening (acute death)
Subacute death causes symmetrical encephalomalacia and haemorrhage in basal ganglia and midbrain
Enterotoxaemia in kids and adult goats