808
edits
Changes
Jump to navigation
Jump to search
no edit summary
==Prognosis==
==Prognosis==
Horses with chronic liver failure due to ragwort poisoning have a poor prognosis for survival as the damage to the liver is severe by the time clinical signs are obvious.
==References==
==References==
* Knottenbelt, D.C. '''A Handbook of Equine Medicine for Final Year Students''' ''University of Liverpool''
* Knottenbelt, D.C. '''A Handbook of Equine Medicine for Final Year Students''' ''University of Liverpool''
==Hepatotoxicity==
==Hepatotoxicity==
*'''pyrrolizidine alkaloids'''
*'''pyrrolizidine alkaloids'''
**toxic principle converted in the body to the toxic intermediate '''pyrroles''' and their esters
**toxic principle converted in the body to the toxic intermediate '''pyrroles''' and their esters
*it is likely that the vascular component of the attempted repair of the chronic damage by fibrosis (really a type of granulation tissue) aids the shunting from the portal triads to the central vein and thereby bypassing the hepatocytes
*it is likely that the vascular component of the attempted repair of the chronic damage by fibrosis (really a type of granulation tissue) aids the shunting from the portal triads to the central vein and thereby bypassing the hepatocytes
*other plant and fungal toxins perform in the same way
*other plant and fungal toxins perform in the same way
[[Category:Hepatotoxicity, Chronic]][[Category:Horse]][[Category:Sheep]]
[[Category:Hepatotoxicity, Chronic]][[Category:Horse]][[Category:Sheep]]
[[Category:To_Do_- lizzyk]]
[[Category:To_Do_- lizzyk]]