Sendai Virus

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Murine Parainfluenza - 1 (Sendai Virus)

Endemic in many mouse colonies
Most mice show no symptoms due to maternal antibodies
But minor respiratory lesions may invalidate carcinogenic or toxicological studies
Immunological studies also confused due to virus activating NK cells via high circulating IF 3-4 days post-infection
Control achieved by:
- Purchasing specific pathogen free (SPF) mice
- Kill whole colony in an outbreak -> disinfection -> formalin fumigation

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