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==Development==

==Development==

===Epidermis===

===Epidermis===

[[image: Section of Monkey Skin.jpg|thumb|250px|right|Monkey epidermis showing the layers present. Copyright RVC2008]]

[[image: Section of Monkey Skin.jpg|thumb|250px|right|Monkey epidermis showing the layers present. ©RVC2008]]

The epidermis is a stratified squamous epithelium and is composed of 4 cell layers anchored to a basal lamina of connective tissue.  Keratinocytes migrate through the epidermis from the basal layer.  This migration begins in the stratum basale, then moves up through the stratum spinosum, stratum granulosum and the stratum corneum.

The epidermis is a stratified squamous epithelium and is composed of 4 cell layers anchored to a basal lamina of connective tissue.  Keratinocytes migrate through the epidermis from the basal layer.  This migration begins in the stratum basale, then moves up through the stratum spinosum, stratum granulosum and the stratum corneum.

*'''Merkel cells'''

*'''Merkel cells'''

These are part of the sensory apparatus of the skin and are located within the '''stratum basale''' of the epidermis where they act as slow-adapting maechanoreceptors.  They are usually closely associated with the afferent myelinated nerve fibres, arranged in a plate-like structure with the base of the Merkel cell, together forming a '''''Merkel's corpuscle'''''.

These are part of the sensory apparatus of the skin and are located within the '''stratum basale''' of the epidermis where they act as slow-adapting mechanoreceptors.  They are usually closely associated with the afferent myelinated nerve fibres, arranged in a plate-like structure with the base of the Merkel cell, together forming a '''''Merkel's corpuscle'''''.

===Dermis===

===Dermis===

*'''Sweat glands'''

*'''Sweat glands'''

Sweat is considered to be the product of [[General Pathology - Necrosis#Apoptosis|apoptosis]] releasing cell contents into the gland lumen, together with secretion where exocytosis, microapocrine blebbing, transcellular and perhaps paracellular processes involved in varying degrees.  Sweat is composed of secretions and cellular debris and includes inorganic ions, water, immunoglobulins, amino acids and waste products including urea and lactic acid.  Equine sweat is rich in proteins including glycoproteins, albumin and gammaglobulins, which cause the sweat to froth and the horse is said to "lather up".

Sweat is considered to be the product of [[Necrosis - Pathology#Apoptosis|apoptosis]] releasing cell contents into the gland lumen, together with secretion where exocytosis, microapocrine blebbing, transcellular and perhaps paracellular processes involved in varying degrees.  Sweat is composed of secretions and cellular debris and includes inorganic ions, water, immunoglobulins, amino acids and waste products including urea and lactic acid.  Equine sweat is rich in proteins including glycoproteins, albumin and gammaglobulins, which cause the sweat to froth and the horse is said to "lather up".

Sweat is degraded by bacteria leading to odour.  Dogs and cats produce very little sweat and use panting to lower body temperature.

Sweat is degraded by bacteria leading to odour.  Dogs and cats produce very little sweat and use panting to lower body temperature.

*[[Lactation - The Mammary Gland - Anatomy & Physiology|'''Mammary glands''']]

*[[Mammary Gland - Anatomy & Physiology|'''Mammary glands''']]

These are greatly modified, enlarged sweat glands and are present in both male and female animals.  Depending on species, they extend from the axillae to the groin, associated with teats and a complex array of sinuses and ducts.  Age, pregnancy and [[Endocrine System - Anatomy & Physiology|endocrine]] factors have an important role in determining glandular activity.

These are greatly modified, enlarged sweat glands and are present in both male and female animals.  Depending on species, they extend from the axillae to the groin, associated with teats and a complex array of sinuses and ducts.  Age, pregnancy and [[Endocrine System Overview - Anatomy & Physiology|endocrine]] factors have an important role in determining glandular activity.

*'''Sebaceous glands'''

*'''Sebaceous glands'''

One or more sebaceous glands surround each '''hair follicle''' at a point about 1/3 of its length beneath the skin's surface.  Each gland is composed of numerous ''acini'' attached to a common '''excretory duct''' through which they discharge their secretions ('''sebum''') onto the hair shaft and epidermis.  In the skin and eyelids such glands release the cell contents together with secretory products with holocrine secretion.  This secretion involves [[General Pathology - Necrosis#Apoptosis|apoptosis]] in which the secretory products and cell debris are released into the gland lumen.  The secretory products vary from species to species and include various fatty acids, diglycerides, cholesterol, diesters, wax esters and giant-ring lactones.

One or more sebaceous glands surround each '''hair follicle''' at a point about 1/3 of its length beneath the skin's surface.  Each gland is composed of numerous ''acini'' attached to a common '''excretory duct''' through which they discharge their secretions ('''sebum''') onto the hair shaft and epidermis.  In the skin and eyelids such glands release the cell contents together with secretory products with holocrine secretion.  This secretion involves [[Necrosis - Pathology#Apoptosis|apoptosis]] in which the secretory products and cell debris are released into the gland lumen.  The secretory products vary from species to species and include various fatty acids, diglycerides, cholesterol, diesters, wax esters and giant-ring lactones.

The function of sebum is that of an emolient of the hair and skin, preventing excessive dryness.  It may combine with '''sweat''' to form an emulsion within the stratum corneum and a form of cement around the hair pores preventing bacterial invasion of the epidermis.  Sebum is also released from the glands during piloerection, as the action of the [[Hair - Anatomy & Physiology#Hair Types|arrector pili]] muscle squeezes the gland as it raises the hair.

The function of sebum is that of an emolient of the hair and skin, preventing excessive dryness.  It may combine with '''sweat''' to form an emulsion within the stratum corneum and a form of cement around the hair pores preventing bacterial invasion of the epidermis.  Sebum is also released from the glands during piloerection, as the action of the [[Hair - Anatomy & Physiology#Hair Types|arrector pili]] muscle squeezes the gland as it raises the hair.

*'''Submental and circumoral glands'''

*'''Submental and circumoral glands'''

Large glands in the [[Lips - Anatomy & Physiology|lip]] region of cats and some rodents; presumed to have a territory marking role.  Circumoral glands are enlarged integumentary glands bordering on the mucocutaneous junctions of the mouth or oral margins associated with greeting and related behaviours, especially in scuiriomorph rodents.

Large glands in the [[Lips|lip]] region of cats and some rodents; presumed to have a territory marking role.  Circumoral glands are enlarged integumentary glands bordering on the mucocutaneous junctions of the mouth or oral margins associated with greeting and related behaviours, especially in scuiriomorph rodents.

 

'''Rabbits''' have scent glands on the chin which are used to mark territory by excreting droplets onto structures in the environment. Male rabbits scent-mark more intensively than female rabbits, and dominant individuals more than subdominant animals. This is correlated with larger scent glands in dominant males.

*'''Inguinal glands'''

*'''Inguinal glands'''

Sexually-related scent glands prominent in ungulates and lagomorphs. They are located at the base of the udders to allow offspring to locate the teats of their mother.

Sexually-related scent glands prominent in ungulates. They are located at the base of the udders to allow offspring to locate the teats of their mother.

*'''Anal sacs'''

 

*[[Anus - Anatomy & Physiology#Species Differences|'''Anal glands''']]

Sebaceous (and modified apocrine in the dog) glands lie within the wall of the anal sacs, with a duct carrying material to the anal opening.  The foul smelling secretion may act as a territorial marker.  Secretions are expressed on defecation.  The secretions are composed of fatty and serous materials with cellular debris.

Sebaceous (and modified apocrine in the dog) glands lie within the wall of the anal sacs, with a duct carrying material to the anal opening.  The foul smelling secretion may act as a territorial marker.  Secretions are expressed on defecation.  The secretions are composed of fatty and serous materials with cellular debris.

==Cutaneous Appendages==

==Cutaneous Appendages==

===Footpads===

===Footpads===

[[image: Section of Dog Footpad.jpg|thumb|250px|right|Thickened skin of the canine footpad. Copyright RVC2008]]

[[image: Section of Dog Footpad.jpg|thumb|250px|right|Thickened skin of the canine footpad. ©RVC2008]]

Cats and Dogs have a digitigrade stance with digital, metacarpal and metatarsal pads in contact with the ground.  A carpal pad is also present, but seems to be superfluous.

Cats and Dogs have a digitigrade stance with digital, metacarpal and metatarsal pads in contact with the ground.  A carpal pad is also present, but seems to be superfluous.

The immune system is involved in several diseases of the skin, with different types of hypersensitivity reactions occuring.

The immune system is involved in several diseases of the skin, with different types of hypersensitivity reactions occuring.

See also [[Skin Immunologic - Pathology|Skin Immunology]]

See also [[:Category:Integumentary System - Immunologic Pathology|Skin Immunology]]

==Species Differences==

==Species Differences==

As the integument of avians, reptiles and amphibians is markedly different to that of mammals, it is covered on another page.

As the integument of avians, reptiles and amphibians is markedly different to that of mammals, it is covered on another page.

[[The Integument of Exotic Species|The Integument Exotic Species]]

[[Integument of Exotic Species - Anatomy & Physiology|The Integument of Exotic Species]]

 

 

 

[[Category:Image Review]]