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=T Cell Tolerance=
 
=T Cell Tolerance=
 
   
 
   
During T cell development within the thymus, genes encoding the T cell receptor are rearranged, resulting in adult cells that are able to recognise antigen fragments displayed by the host MHC molecule. Some receptors however will be self-reactive, i.e. they bind too strongly to antigens expressed by the host's own tissues ('''autoantigens'''). As these cells will induce immune reactions that could be damaging to the host ([[Autoimmune diseases - WikiClinical#Autoimmune diseases|Autoimmunity]]), they must be deleted or suppressed.  
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During T cell development within the thymus, genes encoding the T cell receptor are rearranged, resulting in adult cells that are able to recognise antigen fragments displayed by the host MHC molecule. Some receptors however will be self-reactive, i.e. they bind too strongly to antigens expressed by the host's own tissues ('''autoantigens'''). As these cells will induce immune reactions that could be damaging to the host ([[Autoimmune Diseases - Introduction#Autoimmune diseases|Autoimmunity]]), they must be deleted or suppressed.  
    
==Central Tolerance==
 
==Central Tolerance==
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