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==Pathogenesis==
 
==Pathogenesis==
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Once PRRS virus gains entry to the host, primary replication occurs in regional or mucosal macrophages such as in the tonsil and the nasal and respiratory epithelium. After around twelve hours, viraemia occurs and the virus is disseminated systemically. Lymphatic transport
Following exposure to PRRS virus, primary replication
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occurs in regional or mucosal macrophages (Rossow,
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1998; Rossow et al., 1996a). Typically macrophages of
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the tonsil, nasal and respiratory epithelium are sites of
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primary replication after oronasal exposure. Viremia
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can occur within 12 hours following exposure resulting
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in systemic dissemination of the virus. Lymphatic transport
   
of PRRS virus and virus-infected macrophages to
 
of PRRS virus and virus-infected macrophages to
 
regional lymph nodes is also thought to occur.
 
regional lymph nodes is also thought to occur.
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