Suid Herpesvirus 1
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Also known as Aujeszky's Disease, Pseudorabies, and Mad Itch
Hosts
- Pigs
- Cattle
- Horses
- Cats
- Dogs
- Sheep
Pathogenesis
Sows:
- Aerosol transmission causes bronchopneumonia followed by viremia
- Sows will recover but some may abort
Piglets:
- Virus spreads to neurons, causing encephalitis with convulsions
- Many die within 2 days
Other animals:
- Air-borne virus can infect skin wounds
- Causes pruritis (mad itch) followed by encephalitis
Epidemiology
- Latent virus can be reactivated by mixing new stock in with old
Diagnosis
- ELISA for virus antibody
Control
- England: eradication in the 1980s by serotesting (by ELISA) and culling carriers
- Vaccines in Europe and Ireland
- gE-deleted marker vaccines stimulate cell-mediated immunity