495
edits
Changes
→Cytotoxic CD8+
**Perforins are structurally related to complement factor C9
**Perforins are structurally related to complement factor C9
**Granzymes are proteolytic enzymes that target cell nucleases and cause apoptosis
**Granzymes are proteolytic enzymes that target cell nucleases and cause apoptosis
In both cases direct contact is required between the T cell and target cell, and cell killing can take several minutes.</p><p> Cytotoxic T cells secrete a pattern of cytokines similar to that of TH1 cells i.e. IFN-γ but not IL-2. IFN-γ shifts the balance of the immune response in favour of TH<sub>1</sub> cells giving an increased level of T cell proliferation. The initiation of the immune response via cytotoxic T cells leads to the selective proliferation of cytotoxic T cells enhancing the main mechanism of killing infected cells.</p>
In both cases direct contact is required between the T cell and target cell, and cell killing can take several minutes.</p><p> Cytotoxic T cells secrete a pattern of cytokines similar to that of TH<sub>1</sub> cells i.e. IFN-γ but not IL-2. IFN-γ shifts the balance of the immune response in favour of TH<sub>1</sub> cells giving an increased level of T cell proliferation. The initiation of the immune response via cytotoxic T cells leads to the selective proliferation of cytotoxic T cells enhancing the main mechanism of killing infected cells.</p>
==γδ cells==
==γδ cells==