Difference between revisions of "Urticaria"

Revision as of 14:37, 19 September 2010

Description

Urticaria is a condition of the skin characterised by the development of multiple flat-topped, oedematous swellings (wheals) that dent or 'pit' with digital pressure. Episodes may be acute, chronic or recurrent. The condition occurs in all domestic animals but most commonly in the horse.

Pathogenesis

The aetiopathogenesis of urticaria is complex and many causes have been suggested. The basic pathogenesis is thought to be due to degranulation of mast cells and basophils leading to the release of inflammatory mediators and an increase in vascular permeability. The condition may occur due to exogenous or endogenous hypersensitivity reactions. Exogenous urticaria may occur as a result of exposure to chemicals, medication and insect bites or stings. Endogenous urticaria occurs due to inhalation of allergens.

Signalment

Horses between 1 and 10 years of age are most prone to developing the condition. There is no sex predilection but Thoroughbreds and Arabs appear to be more commonly affected than other breeds.

History and clinical signs

Multiple wheals are often observed and occur within a few minutes or hours of exposure to the causative agent. A history of recurrence or repeated episodes is often reported. Affected areas can vary from small, localised lesions up to 3cm in diameter, to extensive generalised areas involving large areas of skin. Lesions can occur on any part of the body but usually develop on the back, legs, flanks, neck and eyelids. In severe cases the mucous membranes of the nose, mouth, anus and vulva may be involved. Pruritus may or may not be present and the lesions usually disappear rapidly.

Diagnosis

Because of the numerous underlying causes of urticaria, definitive diagnosis may be difficult. Historical and clinical findings may lead to the suspicion of the condition. The localisation of lesions (e.g. site of contact with saddle or insect repellent) or history of medication of exposure to chemicals may help to determine an underlying cause. Dermatographism is a specific pressure-induced type of urticaria in which wheals form in reponse to exogenous pressure. Commonly these are observed in the saddle area of the horse.

Treatment

Acute urticaria often resolves spontaneouly without requiring treatment. Dexamethasone given once at a dose of 0.1 mg/kg IM usually results in resolution of clinical signs within 24 hours. Recurrent cases may require further investigation in order to determine the underlying cause. This may include further investigation of the animal's history and response to withdrawal of drugs or topical products. If no underlying cause is found, an investigation for allergies is indicated and may include intradermal allergy testing, insect control trials and an elimination (novel protein) diet. Biopsy of lesions is generally unrewarding but may reveal a mild to moderate perivascular to interstitial dermatitis. Antihistamines such as Hydroxyzine may be useful in the management of chronic urticaria but are ineffective in treating acute urticaria. Acupuncture has been reported to be effective in one horse.

Prognosis

The prognosis with urticaria is generally favourable because general health is not usually affected.

References

Mair, T. S., Love, S., Schumacher, J., Watson, A. E. (1998) Equine Medicine, Surgery and Reproduction Elsevier Health Sciences
Pascoe, R. R., Knottenbelt, D. C. (1999) Manual of Equine Dermatology Elsevier Health Sciences
Rose, R. J., Hodgson, D. R. (2000) Manual of Equine Practice Elsevier Health Sciences
Scott, D. W., Miller, W. H. (2003) Equine Dermatology Elsevier Health Sciences

@@ Line 2: / Line 2: @@
 ==Description==
-Urticaria is a condition of the skin characterised by multiple oedematous swellings (wheals) that dent or 'pit' with digital pressure. It occurs in all domestic animals but most commonly in the horse.
+Urticaria is a condition of the skin characterised by the development of multiple flat-topped, oedematous swellings (wheals) that dent or 'pit' with digital pressure. Episodes may be acute, chronic or recurrent. The condition occurs in all domestic animals but most commonly in the horse.
 ==Pathogenesis==
-The aetiopathogenesis of urticaria is complex and many causes have been suggested. The basic pathogenesis is thought to be due to degranulation of mast cells and basophils leading to the release of inflammatory mediators and an increase in vascular permeability. Other hypotheses include exogenous or endogenous hypersensitivity reactions. Exogenous urticaria may occur due to chemicals, medication and insect bites or stings. Endogenous urticaria occurs due to inhalation of allergens.
+The aetiopathogenesis of urticaria is complex and many causes have been suggested. The basic pathogenesis is thought to be due to degranulation of mast cells and basophils leading to the release of inflammatory mediators and an increase in vascular permeability. The condition may occur due to exogenous or endogenous hypersensitivity reactions. Exogenous urticaria may occur as a result of exposure to chemicals, medication and insect bites or stings. Endogenous urticaria occurs due to inhalation of allergens.
 ==Signalment==
@@ Line 11: / Line 11: @@
 ==History and clinical signs==
-Multiple wheals are often observed with urticaria and occur within a few minutes or hours of exposure to the causative agent. A history of recurrence or repeated episodes is often reported. Affected areas can vary from small, localised lesions up to 3cm in diameter, to extensive generalised areas involving large areas of skin. Lesions can occur on any part of the body but usually develop on the back, legs, flanks, neck and eyelids. In severe cases the mucous membranes of the nose, mouth, anus and vulva may be involved. . Pruritus may or may not be present and the lesions usually disappear rapidly.
+Multiple wheals are often observed and occur within a few minutes or hours of exposure to the causative agent. A history of recurrence or repeated episodes is often reported. Affected areas can vary from small, localised lesions up to 3cm in diameter, to extensive generalised areas involving large areas of skin. Lesions can occur on any part of the body but usually develop on the back, legs, flanks, neck and eyelids. In severe cases the mucous membranes of the nose, mouth, anus and vulva may be involved.  Pruritus may or may not be present and the lesions usually disappear rapidly.
 ==Diagnosis==
-Because of the numerous underlying causes of urticaria, definitive diagnosis may be difficult. Historical and clinical findings may lead to the suspicion of urticaria. The localisation of lesions (e.g. site of contact with saddle or insect repellent) or history of medication of exposure to chemicals may help to determine an underlying cause. Dermatographism is a specific pressure-induced type of urticaria in which wheals form in reponse to exogenous pressure. Commonly these are observed in the saddle area of the horse.
+Because of the numerous underlying causes of urticaria, definitive diagnosis may be difficult. Historical and clinical findings may lead to the suspicion of the condition. The localisation of lesions (e.g. site of contact with saddle or insect repellent) or history of medication of exposure to chemicals may help to determine an underlying cause. Dermatographism is a specific pressure-induced type of urticaria in which wheals form in reponse to exogenous pressure. Commonly these are observed in the saddle area of the horse.
 ==Treatment==