Changes

*Vaccination sets up memory to the viral infection

*Vaccination sets up memory to the viral infection

*High levels of [[T cell differentiation - WikiBlood#Cytotoxic T-Cells|cytotoxic T cells]] and neutralising [[Immunoglobulins|antibody]] are activated in 1-2 days as a [[B cell differentiation#Secondary T Cell Dependent Response|secondary response]] (instead of 4-10 days as a [[B cell differentiation#T-Cell Dependent Response|primary response]])

*High levels of [[T cell differentiation#Cytotoxic T-Cells|cytotoxic T cells]] and neutralising [[Immunoglobulins|antibody]] are activated in 1-2 days as a [[B cell differentiation#Secondary T Cell Dependent Response|secondary response]] (instead of 4-10 days as a [[B cell differentiation#T-Cell Dependent Response|primary response]])

*The infection is therefore prevented from taking hold causing lesions to develop

*The infection is therefore prevented from taking hold causing lesions to develop

*Different subtypes of [[Lymphocytes#Helper CD4+|T helper cells]] are stimulated by different adjuvants

*Different subtypes of [[Lymphocytes#Helper CD4+|T helper cells]] are stimulated by different adjuvants

**E.g. Aluminium salts generate bias [[T cell differentiation - WikiBlood#TH2 Cells|T helper II]] responses for [[Immunoglobulins|'''antibody''']]-mediated immunity

**E.g. Aluminium salts generate bias [[T cell differentiation#TH2 Cells|T helper II]] responses for [[Immunoglobulins|'''antibody''']]-mediated immunity

**E.g. Killed mycobacteria generate IL-12 producing good '''cell'''-mediated immunity

**E.g. Killed mycobacteria generate IL-12 producing good '''cell'''-mediated immunity

*Immunity for the extracellular phase requires neutralising [[Immunoglobulins|'''antibody''']]

*Immunity for the extracellular phase requires neutralising [[Immunoglobulins|'''antibody''']]

**[[Lymphocytes#B Cells|B cells]] needed

**[[Lymphocytes#B Cells|B cells]] needed

**[[T cell differentiation - WikiBlood#TH2 Cells|T helper type II cells]] needed (for the [[MHC - WikiBlood#MHC II|MHC class II pathway]])

**[[T cell differentiation#TH2 Cells|T helper type II cells]] needed (for the [[MHC - WikiBlood#MHC II|MHC class II pathway]])

**Live vaccine can be used

**Live vaccine can be used

**Killed vaccine can be used

**Killed vaccine can be used

*Extracellular bacterial infection needs [[Immunoglobulins|'''antibody''']] production for [[Complement#Opsonisation|opsonisation]] and to activate the [[Complement|complement pathways]]

*Extracellular bacterial infection needs [[Immunoglobulins|'''antibody''']] production for [[Complement#Opsonisation|opsonisation]] and to activate the [[Complement|complement pathways]]

**[[Lymphocytes#B Cells|B cells]] needed

**[[Lymphocytes#B Cells|B cells]] needed

**[[T cell differentiation - WikiBlood#TH2 Cells|T helper type II cells]] needed

**[[T cell differentiation#TH2 Cells|T helper type II cells]] needed

*Vesicular infections can only be cured by organisms being destroyed inside [[Macrophages|'''macrophages''']]

*Vesicular infections can only be cured by organisms being destroyed inside [[Macrophages|'''macrophages''']]

**[[T cell differentiation - WikiBlood#TH1 Cells|T helper type I cells]] needed

**[[T cell differentiation#TH1 Cells|T helper type I cells]] needed

==When do we vaccinate?==

==When do we vaccinate?==