Changes

*A vaccine can be created to provide the specific immunity best suited for fighting the associated infection

*A vaccine can be created to provide the specific immunity best suited for fighting the associated infection

===Immunity to Virus Infection===

===Immunity to Viral Infection===

[[Image:Virus Life Cycle.jpg|thumb|right|200px|Virus Life Cycle - Copyright Dr Brian Catchpole BVetMed PhD MRCVS]]

[[Image:Virus Life Cycle.jpg|thumb|right|200px|Virus Life Cycle - Copyright Dr Brian Catchpole BVetMed PhD MRCVS]]

*The virus life cycle consists of an extracellular phase, a replicative intracellular phase and another extracellular phase spreading viral particles to other cells to begin the life cycle again

The virus life cycle consists of an extracellular phase, a replicative intracellular phase and another extracellular phase spreading viral particles to other cells to begin the life cycle again

*Immunity for the extracellular phase requires neutralising [[Immunoglobulins|'''antibody''']]

Immunity for the extracellular phase requires neutralising [[Immunoglobulins|'''antibody''']]:

**[[Lymphocytes#B Cells|B cells]] needed

*[[Lymphocytes#B Cells|B cells]] needed

**[[T cell differentiation#TH2 Cells|T helper type II cells]] needed (for the [[Major Histocompatability Complexes#MHC II|MHC class II pathway]])

*[[T cell differentiation#TH2 Cells|T helper type II cells]] needed (for the [[Major Histocompatability Complexes#MHC II|MHC class II pathway]])

**Live vaccine can be used

*Live, killed and subunit vaccines can be used

**Subunit vaccine can be used

*Immunity for the intracellular phase requires [[Lymphocytes#Cytotoxic CD8+|'''CD8+ cytotoxic T cells''']]

Immunity for the intracellular phase requires [[Lymphocytes#Cytotoxic CD8+|'''CD8+ cytotoxic T cells''']] and uses the [[Major Histocompatability Complexes#MHC I|MHC class I pathway]].

**[[Major Histocompatability Complexes#MHC I|MHC class I pathway]]

*Only live vaccine can be used to get into cells (entering via the endogenous pathway)

**Only live vaccine can be used to get into cells (entering via the endogenous pathway)

===Immunity to Bacterial Infection===

===Immunity to Bacterial Infection===