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==Diagnosing Cobalamin Deficiency==
 
==Diagnosing Cobalamin Deficiency==
 
Diagnosis of cobalamin deficiency is based on presence of low fasted serum cobalamin level. If the patient is not fasted prior to testing, falsely increased cobalamin concentrations may be noted. [[Nutrition Glossary#Megaloblastic Anaemia|Megaloblastic anaemia]] and [[neutropenia]] with hypersegmentation may be seen on haematology profile.  Diagnosis is also made on clinical signs consistent with deficiency and evaluation of diet.  
 
Diagnosis of cobalamin deficiency is based on presence of low fasted serum cobalamin level. If the patient is not fasted prior to testing, falsely increased cobalamin concentrations may be noted. [[Nutrition Glossary#Megaloblastic Anaemia|Megaloblastic anaemia]] and [[neutropenia]] with hypersegmentation may be seen on haematology profile.  Diagnosis is also made on clinical signs consistent with deficiency and evaluation of diet.  
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== Vitamin B12 and Folate ==
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Serum vitamin B12 and folate concentrations may be useful in diagnosing small intestinal disease in dogs and cats. Historically, the tests have also been used for diagnosis of small intestinal bacterial overgrowth/antibiotic responsive diarrhoea, but the characteristics of these conditions and the clinical utility of the tests for this specific purpose is a source of controversy. A single serum sample is required.
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{| class="wikitable"
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|+
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!Abnormality
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!Interpretation
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|-
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|Low folate
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|Disease of the proximal small intestine
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|-
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|Low Vitamin B12
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|Disease of the distal small intestine, EPI
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|-
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|Low/normal Vitamin B12 with high folate
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|SIBO/ARD. Folate is normal or increased with EPI
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|}
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Test Codes - Please visit www.nwlabs.co.uk or see our current price list for more information
      
==References==
 
==References==
 
<references/>
 
<references/>
<br>13. Vitamin B12 and Folate [[NationWide Laboratories]]
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{{Reviewed Nutrition 1
 
{{Reviewed Nutrition 1
 
|date = 22 May 2015}}
 
|date = 22 May 2015}}
 
{{Waltham}}
 
{{Waltham}}
 
{{OpenPages}}
 
{{OpenPages}}
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[[File:NationWide Logo.jpeg|right|link=https://www.nwlabs.co.uk/|alt=NationWide Logo|240x240px|In Partnership with NationWide Laboratories|frameless|thumb|]]
   
[[Category:Vitamins]]
 
[[Category:Vitamins]]

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